Neoagarotetraose protects mice against intense exercise-induced fatigue damage by modulating gut microbial composition and function.
Neoagarotetraose protects mice against intense exercise-induced fatigue damage by modulating gut microbial composition and function.
复制标题
DOI：
10.1002/mnfr.201600585
复制
发表时间：
2017-08
影响因子：
5.2
通讯作者：
N. Zhang;Xiangzhao Mao;Robert W. Li;Enling Hou;Yuming Wang;C. Xue;Qingjuan Tang
中科院分区：
文献类型：
--
作者：
N. Zhang;Xiangzhao Mao;Robert W. Li;Enling Hou;Yuming Wang;C. Xue;Qingjuan Tang
范围力竭运动压力已成为一个重要的健康问题，胃肠道问题是一个共同的关注，在激烈的运动。在这项研究中，我们研究了新沉香四糖（NAT）在剧烈运动应激下小鼠的抗疲劳作用。材料和方法力竭性运动应激显著削弱小鼠的几个生理和物理参数，包括食物摄入减少、体重减轻和肠上皮屏障完整性受损。我们的数据显示，16天的NAT治疗导致微生物组组成发生了深刻的变化，随后导致肠道微生物组功能潜力的广泛变化。此外，NAT给药显著增加了粪便中总短链脂肪酸的浓度（p < 0.01）。结论：NAT可以保护小鼠免受剧烈运动引起的疲劳，并为NAT作为一种潜在的益生元的机制提供了新的见解。
SCOPE Exhaustive exercise stress has emerged as an important health issue, and gastrointestinal problems are a common concern during intense exercise. In this study, we investigated the potential antifatigue effects of neoagarotetraose (NAT) in mice under intense exercise stress. MATERIALS AND METHODS Exhaustive exercise stress significantly weakened several physiological and physical parameters of the mice, including decreased food intake, reduced body weight, and impaired integrity of the intestinal epithelial barrier. Our data showed that a 16-day NAT treatment resulted in a profound change in microbiome composition, which subsequently led to widespread shifts in the functional potential of the gut microbiome. Furthermore, NAT administration significantly increased the fecal concentration of total short-chain fatty acids (p < 0.01). CONCLUSION Together, our findings suggest that NAT may protect mice against intense exercise-induced fatigue and provide insights into the mechanisms of NAT as a potential prebiotic.