Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis
Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis
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DOI：
10.1001/archneur.57.8.1183
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发表时间：
2000-08-01
影响因子：
--
通讯作者：
Weiner, HL
中科院分区：
文献类型：
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作者：
Khoury, SJ;Guttmann, CRG;Weiner, HL
目的：确定多发性硬化症患者外周血 T 细胞活化标志物的变化是否与疾病活动性相关。 设计：在一项为期 1 年的前瞻性纵向研究中，我们分析了 40 名多发性硬化症患者外周血中活化 T 淋巴细胞百分比的变化，与临床表现和脑部磁共振成像 (MRI) 扫描的变化相关。在获取血样时以及每月神经系统检查时以及在 Kurtzke 扩展残疾状态量表 (EDSS) 和行走指数量表评分时，对患者进行重复的脑部成像（每位患者的 MRI 平均数量为 22 次）。结果：表达激活标记物白细胞介素 2 受体 (CD25)、II 类主要组织相容性复合体 (MHC) (13) 或表面的细胞百分比的变化二肽基肽酶 (CD26) 与 MRI 检测到的病灶体积变化或钆增强病灶数量变化显着相关。 CD25(+)细胞和表达II类MHC的CD4(+)细胞的变化也与复发缓解型疾病患者的EDSS测量的残疾变化相关，并且CD4(+)CD25(+)细胞的变化与复发缓解型疾病患者的发作发生相关。这些相关性取决于以 1 周或 2 周为间隔采样的时间点之间变化的测量结果。结论：通过细胞表面标志物测量的外周 T 淋巴细胞活化与多发性硬化症患者的疾病活动之间存在关联。
Objective: To determine whether changes in activation markers on peripheral blood T cells correlate with disease activity in patients with multiple sclerosis.Design: In a prospective longitudinal study during 1 year, we analyzed the change in percentage of activated T lymphocytes in the peripheral blood of 40 patients with multiple sclerosis in relation to clinical findings and changes on brain magnetic resonance imaging (MRI) scans. The patients underwent repeated imaging of the brain (mean number of MRIs for each patient, 22) at the time blood samples were obtained as well as at monthly neurological examinations, and at the time of scoring on the Kurtzke Expanded Disability Status Scale (EDSS) and ambulation index scale.Results: A change in the percentage of cells expressing the activation markers interleukin 2 receptor (CD25), class II major histocompatibility complex (MHC) (13) or surface dipeptidyl peptidase (CD26) correlated significantly with a change in lesion volume or a change in number of gadolinium-enhancing lesions as detected on MRI. Changes in CD25(+) cells and in CD4(+) cells expressing class II MHC also correlated with changes in disability as measured by EDSS in patients with relapsing-remitting disease, and changes in CD4(+)CD25(+) cells correlated with the occurrence of attacks in patients with relapsing-remitting disease. These correlations are dependent on measurement of changes between time points sampled at 1- or 2-week intervals.Conclusion: There is a linkage between peripheral T-lymphocyte activation as measured by cell surface markers and disease activity in patients with multiple sclerosis.