Indices of skeletal muscle growth in lean and obese Zucker rats.
Indices of skeletal muscle growth in lean and obese Zucker rats.
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瘦和肥胖 Zucker 大鼠骨骼肌生长的指数。
DOI：
10.1093/jn/110.7.1313
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Roy J. Martin
中科院分区：
文献类型：
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作者：
J. F. Shapira;Ingrid Kircher;Roy J. Martin
研究了瘦肉型、肥胖型和配对喂养的Zucker大鼠腓肠肌的骨骼肌生长。用DNA、RNA和蛋白质分析测定骨骼肌细胞密度。测量胫骨和股骨的长度和重量。所有大鼠在15周龄时处死。瘦身大鼠的腓肠肌、总DNA和总蛋白质比自由喂养(Alo)或成对喂养(PFO)肥胖的大鼠更重。瘦大鼠的胫骨更长、更重。瘦肉组的股骨长度更长，而股骨重量在瘦肉组和ALO组之间没有差异。两只大鼠的股骨都比PFO大鼠重。肥胖大鼠的比较显示，ALO大鼠的腓肠肌重量、总DNA和总蛋白高于PFO组。总RNA在瘦肉组和Alo组之间没有差异。胫骨和股骨的比较显示，ALO大鼠的骨骼比PFO大鼠更长、更重。总而言之，在瘦和肥胖的Zucker大鼠之间，后肢的骨骼和腓肠肌的细胞密度有显著的差异。通过对肥胖大鼠的喂养，这种差异变得更加突出。
Skeletal muscle growth was studied in gastrocnemius muscle of lean and obese ad libitum or pair-fed Zucker rats. Skeletal muscle cellularity was determined by DNA, RNA and protein analysis. The length and weight of the tibia and femur were determined. All rats were killed at 15 weeks of age. Lean rats had heavier gastrocnemius, total DNA and total protein than either the ad libitum (ALO) or pair-fed (PFO) obese rats. Lean rats had longer and heavier tibias. Femur length was greater in lean animals while femur weight did not differ between lean and ALO groups. Both had heavier femur than the PFO rats. Comparison of the obese rats revealed that the ALO rats had greater gastrocnemius weight, total DNA and total protein than the PFO group. Total RNA was not different between the lean and ALO group. Comparison of tibias and femurs showed the ALO rats to have longer and heavier bones than the PFO rats. In summary, there are marked differences in the bones of the hindlimb and the cellularity of the gastrocnemius muscle between lean and obese Zucker rats. The differences were accentuated by pair feeding the obese rat.