Cooperation of Amphiphilicity and Smectic Order in Regulating the Self-Assembly of Cholesterol-Functionalized Brush-Like Block Copolymers
Cooperation of Amphiphilicity and Smectic Order in Regulating the Self-Assembly of Cholesterol-Functionalized Brush-Like Block Copolymers
复制标题
两亲性和近晶序协同调控胆固醇功能化刷状嵌段共聚物的自组装
DOI：
10.1021/acs.langmuir.8b01946
复制
发表时间：
2018-09-18
期刊：
影响因子：
3.9
通讯作者：
Zhu, Xiulin
中科院分区：
文献类型：
--
作者：
Li, Lishan;Zhou, Feng;Zhu, Xiulin
纳米颗粒形态对纳米材料的应用具有重要影响。了解纳米粒子的形成机制和指导纳米粒子自组装过程的形态控制已受到广泛关注。本文设计并合成了一系列含有不同亲疏水嵌段比的胆固醇中原的刷状两亲液晶嵌段共聚物PChEMA(m)-b-POEGMA(n)。研究了PChEMA(m)-b-POEGMA(n)嵌段共聚物在不同溶剂（四氢呋喃/H2O、1,4-二氧六环/H2O和n， n -二甲基甲酰胺）中的自组装行为。在1,4-二氧六烷/H2O溶液中观察到具有良好结构的理想胶束聚集体，包括短圆柱形胶束、纳米纤维、片状片状和具有近晶胶束核的椭球状囊泡，其疏水块比不断增加。虽然两亲性和近序性都控制着自组装，但这两个因素在不同溶剂中的平衡是不同的。这种独特的超分子体系为设计具有可调形态的先进功能纳米材料提供了一种新的策略。
Nanoparticle morphology significantly affects the application of nanometer-scale materials. Understanding nanoparticle formation mechanisms and directing morphological control in nanoparticle self-assembly processes have received wide attention. Herein, a series of brush-like amphiphilic liquid crystalline block copolymers, PChEMA(m)-b-POEGMA(n), containing cholesteryl mesogens with different hydrophobic/hydrophilic block ratios were designed and synthesized. The self-assembly behaviors of the resulting PChEMA(m)-b-POEGMA(n) block copolymers in different solvents (tetrahydrofuran/H2O, 1,4-dioxane/H2O, and N,N-dimethylformamide) were investigated in detail. Desirable micellar aggregates with well-organized architectures, including short cylindrical micelles, nanofibers, fringed platelets, and ellipsoidal vesicles with smectic micellar cores, were observed in 1,4-dioxane/H2O with an increasing hydrophobic block ratio. Although both amphiphilicity and smectic order governed the self-assembly, these two factors were differently balanced in the different solvents. This unique supramolecular system provides a new strategy for the design of advanced functional nanomaterials with tunable morphologies.