Dissecting major signaling pathways in prostate cancer development and progression: Mechanisms and novel therapeutic targets.
Dissecting major signaling pathways in prostate cancer development and progression: Mechanisms and novel therapeutic targets.
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DOI：
10.1016/j.jsbmb.2016.07.006
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Njar VCO
中科院分区：
文献类型：
--
作者：
Ramalingam S;Ramamurthy VP;Njar VCO
前列腺癌（PCa）是最常诊断的非皮肤恶性肿瘤，也是男性癌症死亡的主要原因。在初始阶段，前列腺癌的生长依赖于雄激素，因此雄激素剥夺疗法（ADT）可以有效对抗前列腺癌。然而，大多数患者最终会复发，出现雄激素剥夺抵抗表型，称为去势抵抗性前列腺癌（CRPC），这是一种更具侵袭性的癌症形式，目前尚无有效的治疗方法。目前的综述试图涵盖并建立对与前列腺癌发展和去势抵抗有关的一些主要信号传导途径的理解，此外还提出了针对关键信号传导机制的治疗策略。
Prostate cancer (PCa) is the most frequently diagnosed non-cutaneous malignancy and leading cause of cancer mortality in men. At the initial stages, prostate cancer is dependent upon androgens for their growth and hence effectively combated by androgen deprivation therapy (ADT). However, most patients eventually recur with an androgen deprivation-resistant phenotype, referred to as castration-resistant prostate cancer (CRPC), a more aggressive form for which there is no effective therapy presently available. The current review is an attempt to cover and establish an understanding of some major signaling pathways implicated in prostate cancer development and castration-resistance, besides addressing therapeutic strategies that targets the key signaling mechanisms.
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影响因子：
82.9
作者：
Chen, CD;Welsbie, DS;Sawyers, CL
通讯作者：
Sawyers, CL
DOI：
10.1056/nejmoa1315815
发表时间：
2014-09-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Antonarakis ES;Lu C;Wang H;Luber B;Nakazawa M;Roeser JC;Chen Y;Mohammad TA;Chen Y;Fedor HL;Lotan TL;Zheng Q;De Marzo AM;Isaacs JT;Isaacs WB;Nadal R;Paller CJ;Denmeade SR;Carducci MA;Eisenberger MA;Luo J
通讯作者：
Luo J
影响因子：
9.3
作者：
Chandrasekar T;Yang JC;Gao AC;Evans CP
通讯作者：
Evans CP
影响因子：
50.3
作者：
Carver BS;Chapinski C;Wongvipat J;Hieronymus H;Chen Y;Chandarlapaty S;Arora VK;Le C;Koutcher J;Scher H;Scardino PT;Rosen N;Sawyers CL
通讯作者：
Sawyers CL
DOI：
10.1158/1078-0432.ccr-08-2332
发表时间：
2009-03-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Adhami VM;Siddiqui IA;Sarfaraz S;Khwaja SI;Hafeez BB;Ahmad N;Mukhtar H
通讯作者：
Mukhtar H