Abstracts of the Annual Conference of the Asia Pacific Stroke Organization (APSO). Hong Kong, August 30–September 1, 2013
Abstracts of the Annual Conference of the Asia Pacific Stroke Organization (APSO). Hong Kong, August 30–September 1, 2013
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亚太中风组织 (APSO) 香港年会摘要，2013 年 8 月 30 日至 9 月 1 日。
DOI：
10.1159/000353795
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发表时间：
2013
影响因子：
2.9
通讯作者：
["Satz Mengensatzproduktion
中科院分区：
文献类型：
--
作者：
["Satz Mengensatzproduktion
研究背景有报道阿司匹林抵抗与症状性缺血性卒中患者的严重程度和死亡率相关。然而，阿司匹林抵抗和无症状stroke.MethodsFrom 2006年至2009年之间的关系尚不清楚，我们招募了84无中风阿司匹林用户，包括缺血性心脏病或房颤。通过脑MRI确定无症状性脑梗死（SBI）、微出血（MB）和白色高信号（WMH）。血小板反应性报告为阿司匹林反应单位（ARU）。阿司匹林抵抗定义为ARU≥ 550。结果SBIs 9例（12.0%），MBs 10例（13.3%）。阿司匹林抵抗5例（6.0%）。卡方检验显示，阿司匹林抵抗、心房颤动、合并心肌梗塞和严重WMH与SBI的发生相关（P < 0.05）。SBIs组ARU值高于无SBIs组（513.2 ± 74.0vs.448.4 ± 47.7，P < 0.05），调整后ARU值是唯一有意义的因素（OR 1.016，95% CI 1.000 ~ 1.031; P < 0.05）。结论阿司匹林抵抗可能是无症状阿司匹林使用者发生无症状脑梗死的一个指标。
BackgroundIt has been reported that aspirin resistance was correlated with severity and mortality in patients with symptomatic ischemic stroke. However, the relationship between aspirin resistance and silent stroke is unclear.MethodsFrom 2006 to 2009, we recruited 84 stroke-free aspirin users, including those with ischemic heart disease or atrial fibrillation. Silent brain infarcts (SBI), microbleeds (MB) and white matter hyperintensities (WMH) were determined by brain MRI. Platelet reactivity was reported as aspirin reaction unit (ARU). Aspirin resistance was defined as ARU≥550.Results9 (12.0%) patients had SBIs and 10 (13.3%) had MBs. Aspirin resistance was detected in 5 (6.0%) patients. Aspirin resistance, atrial fibrillation, presence of MBs and severe WMH were associated with the presence SBIs in chi-square tests (P < 0.05). ARU value was higher in patients with SBIs than those without (513.2 ± 74.0 vs. 448.4 ± 47.7, P < 0.05), which was the only significant factor after adjustment (OR 1.016, 95% CI 1.000– 1.031; P < 0.05). Patients with lower ARU value or longer duration of aspirin usage did not present with more MBs (P > 0.05).ConclusionAspirin resistance may be an indicator of silence brain infarcts in asymptomatic aspirin users.