CHANGES IN BLOOD GLUTATHIONE CONCENTRATIONS, AND IN ERYTHROCYTE GLUTATHIONE-REDUCTASE AND GLUTATHIONE-S-TRANSFERASE ACTIVITY AFTER RUNNING TRAINING AND AFTER PARTICIPATION IN CONTESTS
CHANGES IN BLOOD GLUTATHIONE CONCENTRATIONS, AND IN ERYTHROCYTE GLUTATHIONE-REDUCTASE AND GLUTATHIONE-S-TRANSFERASE ACTIVITY AFTER RUNNING TRAINING AND AFTER PARTICIPATION IN CONTESTS
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DOI：
10.1007/bf00636224
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发表时间：
1992-04-01
期刊：
影响因子：
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通讯作者：
JANSSEN, GME
中科院分区：
文献类型：
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作者：
EVELO, CTA;PALMEN, NGM;JANSSEN, GME
先前久坐不动的男性（n = 23）和女性（n = 18）在40周后接受了半程马拉松比赛的训练。总血谷胱甘肽在训练20周后增加，并在40周后恢复正常。红细胞谷胱甘肽还原酶活性增加了20周，并在40周后保持升高。这种影响伴随着谷胱甘肽还原酶系数的降低，这表明核黄素存在的增加可能是还原酶活性变化的原因。红细胞谷胱甘肽s -转移酶活性在训练20周后略有增加，而在训练40周后增加更为明显。这可能表明在训练的这一阶段发生了脂质过氧化。参与者在前20周的训练后跑了15公里的比赛，在40周后跑了半程马拉松。血谷胱甘肽在15公里后趋于下降，在半程马拉松后趋于上升。在这两种情况下，它都在比赛后5天恢复了正常水平。红细胞谷胱甘肽还原酶在比赛后1天升高，5天后恢复正常。这也可以用红细胞核黄素含量的同时变化来解释。红细胞谷胱甘肽s -转移酶活性在两场比赛后均有所下降，但在半程马拉松比赛后5天恢复，而在15公里比赛后则没有这种情况。
Previously sedentary men (n = 23) and women (n = 18) were trained to run a half marathon contest after 40 weeks. Total blood glutathione had increased by 20 weeks of training and had returned to normal after 40 weeks. Erythrocyte glutathione reductase activity had increased by 20 weeks and remained elevated after 40 weeks. This effect was accompanied by decreases in glutathione reductase coefficients, which indicated that increases in the presence of riboflavin may have been responsible for the changes in reductase activity. Erythrocyte glutathione S-transferase activity had increased slightly after 20 weeks of training and a much more marked increase was found after 40 weeks. This may have been indicative of the occurrence of lipid peroxidation in this phase of training. The participants ran a 15-km race after the first 20 weeks of training and a half marathon after 40 weeks. Blood glutathione tended to decrease after the 15-km race and increased after the half marathon. In both cases it had returned to normal values 5 days after the race. Erythrocyte glutathione reductase was elevated 1 day after the races, and had returned to normal after 5 days. This could also have been explained from concurrent changes in the riboflavin content of the erythrocytes. Erythrocyte glutathione S-transferase activity decreased after both races, but was restored 5 days after the half marathon while such was not the case after the 15-km race.