Geographical epidemiology of prostate cancer in Great Britain
Geographical epidemiology of prostate cancer in Great Britain
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DOI：
10.1002/ijc.10113
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发表时间：
2002-02-10
影响因子：
6.4
通讯作者：
Elliott, P
中科院分区：
文献类型：
--
作者：
Jarup, L;Best, N;Elliott, P
前列腺癌发病率近年来有所上升，可能与环境暴露有关。接触环境致癌物在地理上不太可能是均匀分布的，这可能会引起在空间分析中可以检测到的疾病发生的变化。我们研究的目的是考察英国45岁-年龄段前列腺癌的空间变异。对1975-1991年选举选区的空间差异进行了研究。泊松回归被用来检查区域、城市化和社会经济影响，而贝叶斯绘图技术被用来评估空间变异性。有迹象表明，前列腺癌风险在地区水平上存在地理差异，范围从0.83(95%可信区间：0.78-0.87)到1.2(95%可信区间：1.1-1.3)。虽然相对风险的范围很窄，但各病区的风险存在显著的异质性。在4个区域内进行的更详细的空间分析没有显示前列腺癌局部地理聚集的任何明确证据。在小范围内没有任何显著的地理变异性，这与在前列腺癌病因学中起强烈作用的地理变化环境因素相抵触。(C)2002年Wiley-Liss，Inc.
Prostate cancer incidence has increased during recent years, possibly linked to environmental exposures. Exposure to environmental carcinogens is unlikely to be evenly distributed geographically, which may give rise to variations in disease occurrence that is detectable in a spatial analysis. The aim of our study was to examine the spatial variation of prostate cancer in Great Britain at ages 45-64 years. Spatial variation was examined across electoral wards from 1975-1991. Poisson regression was used to examine regional, urbanisation and socioeconomic effects, while Bayesian mapping techniques were used to assess spatial variability. There was an indication of geographical differences in prostate cancer risk at a regional level, ranging from 0.83 (95% CI: 0.78-0.87) to 1.2 (95% CI: 1.1-1.3) across regions. There was significant heterogeneity in the risk across wards, although the range of relative risks was narrow. More detailed spatial analyses within 4 regions did not indicate any clear evidence of localised geographical clustering for prostate cancer. The absence of any marked geographical variability at a small-area scale argues against a geographically varying environmental factor operating strongly in the aetiology of prostate cancer. (C) 2002 Wiley-Liss, Inc.