Moisture Damage and Asthma: A Birth Cohort Study
Moisture Damage and Asthma: A Birth Cohort Study
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DOI：
10.1542/peds.2014-1239
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发表时间：
2015-03-01
期刊：
影响因子：
8
通讯作者：
Pekkanen, Juha
中科院分区：
文献类型：
--
作者：
Karvonen, Anne M.;Hyvarinen, Anne;Pekkanen, Juha
背景：过多的水分和可见的霉菌与哮喘风险增加有关。只有几项研究进行了详细的家访，以确定湿气损害和霉菌生长的程度和位置。方法：在出生队列研究中，在孩子平均5个月大的时候进行了结构化的家访。对398例儿童进行随访，直至6岁。6岁时测定特异性免疫球蛋白E浓度。结果：儿童主要生活区(但不是卫生间或其他室内空间)早期的湿气损害和霉菌与前6年发生体检确诊的哮喘、持续性哮喘和呼吸道症状的风险相关。在湿气损害方面，儿童卧室(调整后的优势比：4.82[95%可信区间：1.29-18.02])和客厅(调整后的优势比：7.51[95%可信区间：1.49-37.83])与哮喘的相关性最强。在随访的早期和特应性儿童中，哮喘与哮喘的相关性曾经更强。在有或没有可见霉菌的湿气损害与特应性致敏之间没有发现一致的相关性。结论：儿童主要生活区的湿气损害和婴儿早期的霉菌与哮喘的发生有关。特应性儿童可能更容易受到湿气损害和霉菌的影响。
BACKGROUND: Excess moisture and visible mold are associated with increased risk of asthma. Only a few studies have performed detailed home visits to characterize the extent and location of moisture damage and mold growth.METHODS: Structured home inspections were performed in a birth cohort study when the children were 5 months old (on average). Children (N = 398) were followed up to the age of 6 years. Specific immunoglobulin E concentrations were determined at 6 years.RESULTS: Moisture damage and mold at an early age in the child's main living areas (but not in bathrooms or other interior spaces) were associated with the risk of developing physiciandiagnosed asthma ever, persistent asthma, and respiratory symptoms during the first 6 years. Associations with asthma ever were strongest for moisture damage with visible mold in the child's bedroom (adjusted odds ratio: 4.82 [95% confidence interval: 1.29-18.02]) and in the living room (adjusted odds ratio: 7.51 [95% confidence interval: 1.49-37.83]). Associations with asthma ever were stronger in the earlier part of the follow-up and among atopic children. No consistent associations were found between moisture damage with or without visible mold and atopic sensitization.CONCLUSIONS: Moisture damage and mold in early infancy in the child's main living areas were associated with asthma development. Atopic children may be more susceptible to the effects of moisture damage and mold.