Age and neuropsychologic function in schizophrenia: A decline in executive abilities beyond that observed in healthy volunteers
Age and neuropsychologic function in schizophrenia: A decline in executive abilities beyond that observed in healthy volunteers
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DOI：
10.1016/s0006-3223(00)00240-7
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发表时间：
2000-07-15
影响因子：
10.6
通讯作者：
Tsuang, MT
中科院分区：
文献类型：
--
作者：
Fucetola, R;Seidman, LJ;Tsuang, MT
背景：Kraepelin最初将精神分裂症概念化为一种退行性脑疾病，目前尚不清楚该病的特征是静止性脑病还是脑功能恶化，或者每种情况的周期，通过神经心理学评估对认知功能的评估可以为这个问题提供更多的见解。与健康志愿者相比，很少有精神分裂症患者在广泛的年龄范围内研究年龄对执行功能的影响。方法：我们通过横断面研究，在精神分裂症患者(n=87)和健康对照组(n=94)中考察了年龄与神经心理功能的交互作用，并将受试者分为三个年龄组(20-35，36-49和50-75)，并对其进行广泛的神经心理测试。结果：与对照组相比，精神分裂症患者在大多数神经心理功能上表现出与年龄相关的下降，除抽象能力外，结论：这些结果与以前的报道一致，表明年龄对精神分裂症患者和健康成人的大部分认知方面的影响相似，但它们支持这样的假设，即退行性过程可能导致精神分裂症患者在老年时某些执行功能更快地下降。生物精神病学2000；48：137-146(C)2000生物精神病学学会。
Background: Kraepelin originally conceptualized schizophrenia as a degenerative brain disorder Ir remains unclear whether the illness is characterized bq a static encephalopathy or a deterioration of brain function, or periods of each condition, Assessments of cognitive function, as measured by neuropsychologic assessment, can provide additional insight into this question. Few studies of patients with schizophrenia have investigated the effect of aging on executive functions, in an extensive neuropsychologic battery across a wide age range, compared to healthy volunteers.Methods: We examined the interaction of aging and neuropsychologic function in schizophrenia through a cross-sectional study in patients (n = 87) and healthy control subjects (n = 94), Subjects were divided into three age groups (20-35 36-49, and 50-75), and performance on an extensive neuropsychologic battery was evaluatedResults: Compared to control subjects, patients with schizophrenia demonstrated similar age-related declines across most neuropsychologic functions, with the exception of abstraction ability, in which significant evidence of a more accelerated decline was observed.Conclusions: These results are consistent with previous reports indicating similar age effects on most aspects of cognition in patients with schizophrenia and healthy adults, but they support the hypothesis that a degenerative process may result in a more accelerated decline of some executive functions in older age in schizophrenia. Biol Psychiatry 2000; 48:137-146 (C) 2000 Society of Biological Psychiatry.