Tyrosine phosphorylation of transmembrane ligands for Eph receptors
Tyrosine phosphorylation of transmembrane ligands for Eph receptors
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DOI：
10.1126/science.275.5306.1640
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发表时间：
1997-03-14
期刊：
影响因子：
56.9
通讯作者：
Klein, R
中科院分区：
文献类型：
--
作者：
Bruckner, K;Pasquale, EB;Klein, R
神经系统中的轴突寻路部分由涉及Eph受体酪氨酸激酶（RTK）家族成员及其膜结合配体的细胞间信号传导事件介导。遗传学证据表明，跨膜配体可能在发育中的胚胎中传递信号。跨膜配体Lerk 2的胞质结构域在与Nuk/Cek 5受体胞外域接触后在酪氨酸残基上磷酸化，这表明Lerk 2具有受体样内在信号传导潜力。此外，Lerk 2是血小板衍生生长因子受体的体内底物，这表明Lerk 2信号传导和酪氨酸激酶激活的信号传导级联之间的串扰。Eph受体的跨膜配体不仅作为传统的RTK配体，而且作为受体样信号分子。
Axonal pathfinding in the nervous system is mediated in part by cell-to-cell signaling events involving members of the Eph receptor tyrosine kinase (RTK) family and their membrane-bound ligands. Genetic evidence suggests that transmembrane ligands may transduce signals in the developing embryo. The cytoplasmic domain of the transmembrane ligand Lerk2 became phosphorylated on tyrosine residues after contact with the Nuk/Cek5 receptor ectodomain, which suggests that Lerk2 has receptorlike intrinsic signaling potential. Moreover, Lerk2 is an in vivo substrate for the platelet-derived growth factor, receptor, which suggests crosstalk between Lerk2 signaling and signaling cascades activated by tyrosine kinases. It is proposed that transmembrane ligands of Eph receptors act not only as conventional RTK ligands but also as receptorlike signaling molecules.