A Ceramic-Electrolyte Glucose Fuel Cell for Implantable Electronics
A Ceramic-Electrolyte Glucose Fuel Cell for Implantable Electronics
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DOI：
10.1002/adma.202109075
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发表时间：
2022-05-12
影响因子：
29.4
通讯作者：
Rupp，Jennifer L. M.
中科院分区：
文献类型：
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作者：
Simons，Philipp;Schenk，Steven A.;Rupp，Jennifer L. M.
下一代植入式设备，如传感器、药物输送系统和电疗法，需要高效、可靠和高度小型化的电源。现有的电源，如Li-I2起搏器电池，在不牺牲容量的情况下显示出有限的缩小潜力，因此，需要替代方案来为微型植入物供电。这项工作表明，陶瓷电解质可以用于潜在的植入式葡萄糖燃料电池，具有前所未有的小型化。具体地说，展示了一种基于质子导电电解液CeO2的陶瓷葡萄糖燃料电池，该电池由厚度低于400 nm的独立膜组成，并完全集成到硅中，以便轻松集成到生物电子中。与聚合物膜相比，所有使用的材料都具有高度的温度稳定性，使得植入的热灭菌变得微不足道。该产品的峰值功率密度为43µW cm−2，并通过专门设计的测试设备和协议，对150个开路电压器件和12个功率密度器件的成功制造和电化学功能进行了异常高的统计验证。研究结果表明，基于陶瓷的微型葡萄糖燃料电池是迄今为止最小的潜在植入式电源，是为下一代高度小型化的植入式医疗设备提供动力的可行选择。
Next‐generation implantable devices such as sensors, drug‐delivery systems, and electroceuticals require efficient, reliable, and highly miniaturized power sources. Existing power sources such as the Li–I2pacemaker battery exhibit limited scale‐down potential without sacrificing capacity, and therefore, alternatives are needed to power miniaturized implants. This work shows that ceramic electrolytes can be used in potentially implantable glucose fuel cells with unprecedented miniaturization. Specifically, a ceramic glucose fuel cell—based on the proton‐conducting electrolyte ceria—that is composed of a freestanding membrane of thickness below 400 nm and fully integrated into silicon for easy integration into bioelectronics is demonstrated. In contrast to polymeric membranes, all materials used are highly temperature stable, making thermal sterilization for implantation trivial. A peak power density of 43 µW cm−2, and an unusually high statistical verification of successful fabrication and electrochemical function across 150 devices for open‐circuit voltage and 12 devices for power density, enabled by a specifically designed testing apparatus and protocol, is demonstrated. The findings demonstrate that ceramic‐based micro‐glucose‐fuel‐cells constitute the smallest potentially implantable power sources to date and are viable options to power the next generation of highly miniaturized implantable medical devices.