Moderate alcohol consumption, dietary fat composition, and abdominal obesity in women: Evidence for gene-environment interaction
Moderate alcohol consumption, dietary fat composition, and abdominal obesity in women: Evidence for gene-environment interaction
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DOI：
10.1210/jc.2003-030851
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发表时间：
2003-11-01
影响因子：
5.8
通讯作者：
Campbell, LV
中科院分区：
文献类型：
--
作者：
Greenfield, JR;Samaras, K;Campbell, LV
我们研究了酒精摄入量、膳食脂肪组成、全身脂肪（TBF）和中央腹部脂肪（CAF）之间的关系，独立于遗传混杂因素，并评估了遗传易感性的调节作用。我们研究了334名女性双胞胎（57.7 +/- 6.7岁）排除饮食报道不足。饮食通过食物频率问卷进行评估，体脂通过双能X线吸收法进行评估。适度饮酒者（12-17.9 g/d）的TBF（20.6 +/- 5.6 vs. 24.8 +/- 8.4 kg，P = 0.03）和CAF（1.2 +/- 0.6 vs. 1.6 +/- 0.7 kg，P = 0.03）低于戒酒者。在多元回归分析中，饮酒量仍然与体脂分布独立相关。在cotwin病例对照（单卵双胞胎）分析，适度饮酒占300克CAF少，独立的遗传和其他环境因素。基因-环境交互作用分析表明，这种关联仅限于腹型肥胖遗传风险高的受试者。膳食脂肪组成与肥胖无相关性。然而，在腹部肥胖遗传风险较低的女性中，多不饱和脂肪摄入量在最高三分位数的受试者的CAF比摄入量在最低三分位数的受试者低约50%（0.9 +/- 0.4 vs 1.6 +/- 0.4 kg，P = 0.0007），在高遗传风险的受试者中不存在这种关联。总之，遗传风险调节饮食因素和肥胖之间的关系。下腹部脂肪可能介导饮食摄入和2型糖尿病风险之间的关联。
We examined relationships among alcohol intake, dietary fat composition, and total body fat (TBF) and central abdominal fat (CAF), independent of genetic confounders, and evaluated the modulating effect of genetic susceptibility. We studied 334 female twins (57.7 +/- 6.7 yr) after excluding dietary underreporters. Diet was assessed by Food-Frequency Questionnaire and body fat by dual-energy x-ray absorptiometry. Moderate alcohol consumers (12-17.9 g/d) had less TBF (20.6 +/- 5.6 vs. 24.8 +/- 8.4 kg, P = 0.03) and CAF (1.2 +/- 0.6 vs. 1.6 +/- 0.7 kg, P = 0.03) than abstainers. In multiple regression, alcohol consumption remained independently associated with body fat distribution. In cotwin case-control (monozygotic twin) analysis, moderate alcohol consumption accounted for 300 g less CAF, independent of genetic and other environmental factors. Gene-environment interaction analysis indicated that this association was limited to subjects at high genetic risk of abdominal obesity. There was no relationship between dietary fat composition and adiposity. However, in women at low genetic risk of abdominal obesity, subjects with polyunsaturated fat intakes in the highest tertile had about 50% less CAF than subjects with intakes in the lowest tertile (0.9 +/- 0.4 vs. 1.6 +/- 0.4 kg, P = 0.0007), an association absent in subjects with high genetic risk. In conclusion, genetic risk modulates relationships between dietary factors and adiposity. Lower abdominal fat may mediate associations between dietary intake and type 2 diabetes risk.