Familial Risk for Mood Disorder and the Personality Risk Factor, Neuroticism, Interact in Their Association with Frontolimbic Serotonin 2A Receptor Binding
Familial Risk for Mood Disorder and the Personality Risk Factor, Neuroticism, Interact in Their Association with Frontolimbic Serotonin 2A Receptor Binding
复制标题
DOI：
10.1038/npp.2009.218
复制
发表时间：
2010-04-01
影响因子：
7.6
通讯作者：
Knudsen, Gitte Moos
中科院分区：
文献类型：
--
作者：
Frokjaer, Vibe G.;Vinberg, Maj;Knudsen, Gitte Moos
生活压力是日后出现情绪障碍的一个重要危险因素，特别是对于有家族风险的个体而言。同样，人格特质神经质得分高与情绪障碍的风险增加相关。神经质部分反映了应激脆弱性，并且与额叶血清素 2A (5-HT(2A)) 受体结合呈正相关。在这里，我们研究神经质是否与额叶 5-HT(2A) 受体结合相关的家族风险相互作用。其中包括 21 名有情绪障碍史的健康双胞胎和 16 名没有情绪障碍史的健康双胞胎。他们回答了自我报告的人格问卷，并接受了[(18)F]阿坦色林正电子发射断层扫描。在调整年龄和体重指数的分析中，我们发现神经质和家族风险之间在预测额边缘 5-HT(2A) 受体结合方面存在显着的相互作用 (p = 0.026)。仅在高危组中，神经质与额叶 5-HT(2A) 受体结合呈正相关 (p = 0.0037)。总之，我们的数据表明，家族风险和神经质在与额叶 5-HT(2A) 受体结合的关系中相互作用。这些发现表明，遗传和人格风险因素与情绪障碍的易感性之间存在看似合理的神经生物学联系。它有助于我们理解为什么一些高危人群会出现情绪障碍，而另一些人却不会。我们推测，情绪障碍家族高风险个体的应激反应性增加可能会增强神经质在塑造潜在环境压力影响方面的作用，从而影响血清素能神经传递。神经精神药理学 (2010) 35, 1129-1137; doi：10.1038/npp.2009.218； 2009 年 12 月 30 日在线发布
Life stress is a robust risk factor for later development of mood disorders, particularly for individuals at familial risk. Likewise, scoring high on the personality trait neuroticism is associated with an increased risk for mood disorders. Neuroticism partly reflects stress vulnerability and is positively correlated to frontolimbic serotonin 2A (5-HT(2A)) receptor binding. Here, we investigate whether neuroticism interacts with familial risk in relation to frontolimbic 5-HT(2A) receptor binding. Twenty-one healthy twins with a co-twin history of mood disorder and 16 healthy twins without a co-twin history of mood disorder were included. They answered self-report personality questionnaires and underwent [(18)F] altanserin positron emission tomography. We found a significant interaction between neuroticism and familial risk in predicting the frontolimbic 5-HT(2A) receptor binding (p = 0.026) in an analysis adjusting for age and body mass index. Within the high-risk group only, neuroticism and frontolimbic 5-HT(2A) receptor binding was positively associated (p = 0.0037). In conclusion, our data indicate that familial risk and neuroticism interact in their relation to frontolimbic 5-HT(2A) receptor binding. These findings point at a plausible neurobiological link between genetic and personality risk factors and vulnerability to developing mood disorders. It contributes to our understanding of why some people at high risk develop mood disorders while others do not. We speculate that an increased stress reactivity in individuals at high familial risk for mood disorders might enhance the effect of neuroticism in shaping the impact of potential environmental stress and thereby influence serotonergic neurotransmission. Neuropsychopharmacology (2010) 35, 1129-1137; doi: 10.1038/npp.2009.218; published online 30 December 2009