Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling?
Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling?
复制标题
DOI：
10.1016/j.clcc.2011.03.001
复制
发表时间：
2011-06
影响因子：
3.4
通讯作者：
Venook AP
中科院分区：
文献类型：
--
作者：
Kelley RK;Venook AP
II期结肠癌的常规临床和病理危险因素提供的预后信息有限，不能预测对基于5-氟尿嘧啶的辅助化疗的反应。需要新的预后和预测性生物标志物来识别具有最高复发风险的患者，这些患者将从辅助化疗中获得最大的绝对风险降低。我们在下面回顾了淋巴结阴性结肠癌患者的传统危险因素的证据，然后讨论了这种恶性肿瘤有前途的新分子和遗传标记。基因表达谱是一种新兴的工具，在肿瘤学中具有预后和预测潜力。对于II期结肠癌患者，Oncotype DX结肠癌检测现在可作为预后标志物商业化，ColoPrint检测预计将于今年晚些时候发布。下文描述了这两种检测方法的现有证据，最后讨论了结肠癌风险分层和治疗决策中基因表达谱的潜在未来方向。
Conventional clinical and pathologic risk factors in stage II colon cancer provide limited prognostic information and do not predict response to adjuvant 5-fluorouracil-based chemotherapy. New prognostic and predictive biomarkers are needed to identify patients with highest recurrence risk who will receive the greatest absolute risk reduction from adjuvant chemotherapy. We review below the evidence for conventional risk factors in node-negative colon cancer patients, followed by a discussion of promising new molecular and genetic markers in this malignancy. Gene expression profiling is an emerging tool with both prognostic and predictive potential in oncology. For stage II colon cancer patients, the Oncotype DX Colon Cancer test is now commercially available as a prognostic marker, and the ColoPrint assay is expected to be released later this year. Current evidence for both of these assays is described below, concluding with a discussion of potential future directions for gene expression profiling in colon cancer risk stratification and treatment decision-making.
登录
查看更多内容
影响因子：
9
作者：
Croner, Roland S.;Foertsch, Thomas;Lausen, Berthold
通讯作者：
Lausen, Berthold
宇宙（癌症中的体细胞突变目录）数据库和网站。
影响因子：
8.8
作者：
Bamford, S;Dawson, E;Forbes, S;Clements, J;Pettett, R;Dogan, A;Flanagan, A;Teague, J;Futreal, PA;Stratton, MR;Wooster, R
通讯作者：
Wooster, R
影响因子：
168.9
作者：
Gray, Richard;Barnwell, Jennifer;Kerr, David J.
通讯作者：
Kerr, David J.
影响因子：
45.3
作者：
Bertagnolli, Monica M.;Niedzwiecki, Donna;Redston, Mark
通讯作者：
Redston, Mark
影响因子：
45.3
作者：
Del Rio, Maguy;Molina, Franck;Ychou, Marc
通讯作者：
Ychou, Marc