Calibrated quantitative ultrasound imaging of skeletal muscle using backscatter analysis
Calibrated quantitative ultrasound imaging of skeletal muscle using backscatter analysis
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DOI：
10.1002/mus.21052
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发表时间：
2008-07-01
期刊：
影响因子：
3.4
通讯作者：
Pestronk, Alan
中科院分区：
文献类型：
--
作者：
Zaidman, Craig M.;Holland, Mark R.;Pestronk, Alan
我们评估了超声方法的能力，该方法可以表征心肌病理学，并在不同的成像系统中具有可靠性，以获得骨骼肌后向散射的校准定量估计。我们的程序利用组织模仿体模建立超声灰度和反向散射水平之间的线性关系。我们研究了82名成年人的骨骼肌：45名对照组和37名遗传性肌病患者。我们发现骨骼肌超声背向散射水平随探头方向、年龄、肌肉收缩和病理而变化。与横向平面相比，纵向探头的可靠性更高。后向散射水平在40岁以上的患者中更高，肌肉伸展比屈曲，肌病患者比对照组更高。肌肉背散射的校准测量在识别和可靠地测量骨骼肌病理水平方面具有灵敏度和特异性。
We evaluated the ability of an ultrasound method, which can characterize cardiac muscle pathology and has reliability across different imaging systems, to obtain calibrated quantitative estimates of backscatter of skeletal muscle. Our procedure utilized a tissue-mimicking phantom to establish a linear relationship between ultrasound grayscale and backscatter levels. We studied skeletal muscles of 82 adults: 45 controls and 37 patients with hereditary myopathies. We found that skeletal muscle ultrasound backscatter levels varied with probe orientation, age, and muscle contraction and pathology. Reliability was greater with the probe in longitudinal compared with transverse planes. Backscatter levels were higher in those >40 years of age, in muscle extension than flexion, and in myopathic patients than controls. Calibrated measurements of muscle backscatter have sensitivity and specificity in identifying and reliably measuring levels of skeletal muscle pathology.