Cyst and host tissue concentrations of mebendazole in patients undergoing surgery for hydatid disease
Cyst and host tissue concentrations of mebendazole in patients undergoing surgery for hydatid disease
复制标题
包虫病手术患者囊肿和宿主组织中甲苯咪唑的浓度
DOI：
--
复制
发表时间：
1983
影响因子：
11.4
通讯作者：
M. Roberts
中科院分区：
文献类型：
--
作者：
P. Braithwaite;R. J. Allan;M. Dawson;T. R. Watson;M. Roberts
采用高效液相色谱法测定血浆、宿主组织和包虫材料中甲苯咪唑的水平，这些材料取自四名接受包虫病手术的患者。药物被吸收并渗透到宿主和寄生虫物质中。活的包虫囊肿中的药物水平远低于死亡的囊肿。通过活的包虫囊肿排除或解毒药物的可能性提高。
Mebendazole levels were assayed by high performance liquid chromatographic assay in plasma, host tissues, and hydatid material taken from four patients who underwent surgery for hydatid disease. The drug was absorbed and had penetrated both into the host and into the parasite material. The levels of the drug in viable hydatid cysts were much lower than those in dead cysts. The possibility of exclusion or detoxification of the drug by viable hydatid cysts is raised.