Dorsolateral Prefrontal Cortex Enables Updating of Established Memories.
Dorsolateral Prefrontal Cortex Enables Updating of Established Memories.
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DOI：
10.1093/cercor/bhy298
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发表时间：
2018-12
期刊：
影响因子：
3.7
通讯作者：
L. M. Kluen;L. Dandolo;G. Jocham;L. Schwabe
中科院分区：
文献类型：
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作者：
L. M. Kluen;L. Dandolo;G. Jocham;L. Schwabe
根据新信息更新已建立的记忆是记忆指导未来行为的基础。然而，人们对更新现有记忆的大脑机制知之甚少。在这里，我们结合功能磁共振成像和多变量表征相似性分析来阐明巩固记忆更新的神经机制。为此，参与者首先学习面孔-城市名称对。二十四小时后，当参与者躺在核磁共振扫描仪中时，他们被要求更新其中一些关联，但不更新其他关联，并编码全新的配对。 24小时后再次测试更新成功。我们的结果表明，背外侧前额叶皮层（dlPFC）的活动增加，特别是在更新现有关联期间，其明显强于需要简单检索或新编码时。 dlPFC 的更新相关活动及其与海马体的功能连接与更新成功直接相关。此外，dlPFC 中更新项目的神经相似性明显更高，并且 dlPFC 神经相似性的增加将具有高更新性能的个体与具有低更新性能的个体区分开来。总之，这些发现表明 dlPFC 在更新既定记忆中发挥着关键作用，可能与海马体相互作用。
Updating established memories in light of new information is fundamental for memory to guide future behavior. However, little is known about the brain mechanisms by which existing memories can be updated. Here, we combined functional magnetic resonance imaging and multivariate representational similarity analysis to elucidate the neural mechanisms underlying the updating of consolidated memories. To this end, participants first learned face-city name pairs. Twenty-four hours later, while lying in the MRI scanner, participants were required to update some of these associations, but not others, and to encode entirely new pairs. Updating success was tested again 24 h later. Our results showed increased activity of the dorsolateral prefrontal cortex (dlPFC) specifically during the updating of existing associations that was significantly stronger than when simple retrieval or new encoding was required. The updating-related activity of the dlPFC and its functional connectivity with the hippocampus were directly linked to updating success. Furthermore, neural similarity for updated items was markedly higher in the dlPFC and this increase in dlPFC neural similarity distinguished individuals with high updating performance from those with low updating performance. Together, these findings suggest a key role of the dlPFC, presumably in interaction with the hippocampus, in the updating of established memories.