mTOR Signaling in Growth, Metabolism, and Disease.
mTOR Signaling in Growth, Metabolism, and Disease.
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DOI：
10.1016/j.cell.2017.02.004
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发表时间：
2017-03-09
期刊：
影响因子：
64.5
通讯作者：
Sabatini DM
中科院分区：
文献类型：
--
作者：
Saxton RA;Sabatini DM
雷帕霉素的机制靶点（mTOR）协调真核细胞的生长和代谢与环境输入，包括营养物质和生长因子。过去二十年的广泛研究已经确立了mTOR在调节许多基本细胞过程中的核心作用，从蛋白质合成到自噬，并且mTOR信号的失调与癌症和糖尿病的进展以及衰老过程有关。在这里，我们回顾了mTOR功能、调控及其在哺乳动物生理学中的重要性的最新进展。我们还强调了mTOR信号网络对人类疾病的影响，并讨论了临床治疗靶向mTOR的当前和未来前景。
The mechanistic Target of Rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs including nutrients and growth factors. Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progression of cancer and diabetes, as well as the aging process. Here, we review recent advances in our understanding of mTOR function, regulation, and importance in mammalian physiology. We also highlight how the mTOR-signaling network contributes to human disease, and discuss the current and future prospects for therapeutically targeting mTOR in the clinic.