Unapparent Microsporidial Infection among Immunocompetent Humans in the Czech Republic
Unapparent Microsporidial Infection among Immunocompetent Humans in the Czech Republic
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DOI：
10.1128/jcm.01147-10
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发表时间：
2011-03-01
影响因子：
9.4
通讯作者：
Kvac, Martin
中科院分区：
文献类型：
--
作者：
Sak, Bohumil;Brady, Daniel;Kvac, Martin
在目前的人群为基础的研究中，我们确定了最常见的人类致病性微孢子虫，脑孢子虫属的患病率。和比氏肠胞虫，在无症状的健康人生活在捷克共和国。共有382名居住在捷克共和国的男性和女性（年龄在1至84岁之间），其中265名是捷克国民，117名是外国学生，他们被纳入了一项研究，通过使用粪便学和分子方法检测微孢子虫的存在。分别检测到9个和136个个体的比氏肠胞虫或脑胞虫的单种感染。此外，14人被检测到合并感染。3种人类致病性脑孢子虫的4种基因型7 E.检测到bieneusi基因型，包括3种新基因型。其中一些是首次在人类中报道。患病率最高的是50岁以上的人和松散的未成形粪便样本。这些发现清楚地表明，接触微孢子虫在免疫功能正常的人群中很常见，微孢子虫病与健康人群的任何临床表现无关。
In the present population-based study, we determined the prevalences of the most common human-pathogenic microsporidia, Encephalitozoon spp. and Enterocytozoon bieneusi, in asymptomatic healthy people living in the Czech Republic. A total of 382 males and females (ages, 1 to 84 years) living in the Czech Republic, of whom 265 were Czech nationals and 117 were foreign students, were included in a study testing for the presence of microsporidia by use of coprology and molecular methods. Single-species infections with Enterocytozoon bieneusi or an Encephalitozoon sp. were detected for 9 and 136 individuals, respectively. Moreover, coinfections were detected for 14 individuals. Four genotypes of 3 human-pathogenic Encephalitozoon spp. and 7 E. bieneusi genotypes, including 3 novel genotypes, were detected. Some of these were reported in humans for the first time. The highest prevalence was recorded for individuals older than 50 years and for loose, unformed stool samples. These findings clearly show that exposure to microsporidia is common among immunocompetent people and that microsporidiosis is not linked to any clinical manifestation in healthy populations.