An Association Analysis between Mitochondrial DNA A10398G Polymorphism and Temperament in Japanese Young Adults
An Association Analysis between Mitochondrial DNA A10398G Polymorphism and Temperament in Japanese Young Adults
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DOI：
10.1371/journal.pone.0007763
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发表时间：
2009-11-09
期刊：
影响因子：
3.7
通讯作者：
Shidoji, Yoshihiro
中科院分区：
文献类型：
--
作者：
Kishida, Kunihiro;Tominaga, Mihoko;Shidoji, Yoshihiro
线粒体（mt）DNA C5178 A和A10398 G多态性已被报道与精神障碍，如双相情感障碍。然而，这些多态性对健康人气质的影响知之甚少。评估健康的受试者可以为保持心理健康和预防精神疾病提供新的策略。我们研究了日本学生mtDNA多态性与气质之间的关系。基因型、5178-10398单倍型和性别对气质的影响无显著性差异。基于性别的亚组分析表明，mtDNA A10398 G多态性与性别在焦虑和强迫中存在交互作用。这一发现是初步的，由于样本量小（144例受试者）和多重统计检验，不能排除假阳性的可能性。进一步的研究，涉及更大的样本量或其他种族群体是必要的，以确认mtDNA A10398 G多态性可以是一个遗传因素的气质。
The mitochondrial (mt) DNA C5178A and A10398G polymorphisms have been reported to be associated with mental disorders such as bipolar disorder. However, the effects of these polymorphisms on temperament in healthy people are poorly understood. Evaluating healthy subjects can have the advantage of providing new strategies for maintaining psychological health and preventing mental illness. We examined the association between mtDNA polymorphisms and temperament in Japanese students. There was no significant difference in examined temperament when analysed by genotypes, 5178-10398 haplotypes, or sex. The subgroup analysis based on sex indicated that there was an interactive effect of the mtDNA A10398G polymorphism and sex on anxiety and obsession. This finding is preliminary and cannot exclude the possibility of false-positive due to small sample size (144 subjects) and multiple statistical testing. Further studies involving a larger sample size or other ethnic groups are necessary to confirm that mtDNA A10398G polymorphism can be a genetic factor for temperament.