Blood thrombogenicity in type 2 diabetes mellitus patients is associated with glycemic control
Blood thrombogenicity in type 2 diabetes mellitus patients is associated with glycemic control
复制标题
DOI：
10.1016/s0735-1097(01)01555-8
复制
发表时间：
2001-11-01
影响因子：
24
通讯作者：
Crandall, JP
中科院分区：
文献类型：
--
作者：
Osende, JI;Badimon, JJ;Crandall, JP
目的本研究旨在探讨2型糖尿病(T2 DM)患者的血栓形成与慢性血糖控制是否相关。动脉粥样硬化和动脉血栓并发症发生率高。血栓形成增加是否与血糖控制有关还没有正确的研究。方法选择40例糖化血红蛋白(HbA1c)大于或等于7.5%的2型糖尿病患者。维持目前的降糖治疗，患者被随机分为保守组(饮食调整加安慰剂)或强化组。(饮食调整加曲格列酮)降血糖方案，疗程3个月。在基线和三个月后，用Badimon体外灌注室测量血液的血栓形成能力，并评估血小板血栓的形成。结果两组患者(保守组和强化组分别为48%和74%)血糖控制得到改善(HbA1c下降大于或等于0.5%)，血栓形成能力明显降低。血栓形成的减少与HbA1c的降低呈显著正相关(r=0.47，P
Objectives This study was designed to determine whether blood thrombogenicity is related to chronic glycemic control in type 2 diabetes mellitus (T2DM).Background Type 2 diabetes mellitus is associated with accelerated. atherosclerosis and a high rate of arterial thrombotic complications. Whether increased blood thrombogenicity is associated with glycemic control has not been properly tested.Methods Forty patients with T2DM with hemoglobin A1c (HbA1c) greater than or equal to7.5% were selected. Maintaining their current hypoglycemic therapies, patients were randomized into a conservative (diet modification plus placebo) or intensive. (diet modification plus troglitazone) hypoglycemic regimen for three months. Blood thrombogenicity was measured at baseline and after three months with the Badimon ex vivo perfusion chamber and assessed as platelet-thrombus formation. The repeated measurements allowed every patient to be his/her own control.Results Patients in both groups (48% and 74% of the conservative and intensive groups, respectively) improved glucose control (HbA1c reduction greater than or equal to0.5%), showing a significant decrease in blood thrombogenicity. A significant positive correlation was observed between the reduction in thrombus formation and the reduction in HbA1c (r=0.47, p