Association of the insulin resistance syndrome and microalbuminuria among nondiabetic Native Americans. The Inter-Tribal Heart Project
Association of the insulin resistance syndrome and microalbuminuria among nondiabetic Native Americans. The Inter-Tribal Heart Project
复制标题
DOI：
10.1097/01.asn.0000015762.92814.85
复制
发表时间：
2002-06-01
影响因子：
13.6
通讯作者：
McClellan, WM
中科院分区：
文献类型：
--
作者：
Hoehner, CM;Greenlund, KJ;McClellan, WM
本研究调查了非糖尿病的美洲原住民中微量白蛋白尿和胰岛素抵抗综合征（IRS）之间的关系。在一个横断面调查中。年龄分层的随机抽样从印度卫生服务诊所名单为一个梅诺米尼和两个齐佩瓦保留。从体格检查中收集信息。个人采访。还有血液和尿液样本采用随机点尿法测定尿白蛋白：肌酐比值（ACR）。IRS由复合性状的数量定义：高血压、空腹血糖受损（IFG）。高空腹胰岛素低高密度脂蛋白胆固醇和高胆固醇血症。在934名合格的非糖尿病参与者中。15.2%出现微量白蛋白尿。一个的流行。两个. 3个或3个以上性状分别占27.0%、16.6%和7.4%。分别在控制了年龄之后。性，吸烟，体重指数教育糖尿病和肾脏疾病家族史中，微量白蛋白尿的优势比（OR）为1.8（95%可信区间[CI]）。1.1~ 2.8），1.8（95%CI. 1.0 2个性状的变异系数为2.3（95%CI. 1.1到4.9）对于三个或更多的特征（与没有特征相比），与男性相比，A预兆中的关联模式似乎较弱。在个体IRS特征中，只有高血压和IFG与微量白蛋白尿相关。在这些非糖尿病的美洲原住民中。IRS与微量白蛋白尿患病率的两倍增加有关。健康促进工作应侧重于降低高血压的流行率。以及葡萄糖耐受不良和肥胖症。肾脏和心血管疾病的高危人群。
This study investigated the association between microalbuminuria and the insulin resistance syndrome (IRS) among nondiabetic Native Americans. In a cross-sectional survey. age-stratified random samples were drawn from the Indian Health Service clinic lists for one Menominee and two Chippewa reservations. Information was collected from physical examinations. personal interviews. and blood and urine samples. The urinary albumin:creatinine ratio (ACR) was measured using a random spot urine sample. The IRS was defined by the number of composite traits: hypertension, impaired fasting glucose (IFG). high fasting insulin, low HDL cholesterol. and hypertriglyceridemia. Among the 934 eligible nondiabetic participants. 15.2% exhibited microalbuminuria. The prevalence of one. two. and three or more traits was 27.0, 16.6 and 7.4%. respectively. After controlling for age. sex, smoking, body mass index. education. and family histories of diabetes and kidney disease, the odds ratio (OR) for microalbuminuria was 1.8 (95% confidence interval [CI]. 1.1 to 2.8) for one IRS trait, 1.8 (95% Cl. 1.0 to 3,2) for two traits, and 2.3 (95% Cl. 1.1 to 4.9) for three or more traits (versus no traits), The pattern of association appeared weaker among A omen compared with men. Of the individual IRS traits, only hypertension and IFG were associated with microalbuminuria. Among these nondiabetic Native Americans. the IRS was associated with a twofold increased prevalence of microalbuminuria. Health promotion efforts should focus on lowering the prevalence of hypertension. as well as glucose intolerance and obesity. in this population at high risk for renal and cardiovascular disease.