Genetic analysis of H3 subtype influenza viruses isolated from domestic ducks in northern China during 2004-2005
Genetic analysis of H3 subtype influenza viruses isolated from domestic ducks in northern China during 2004-2005
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DOI：
10.1007/s11262-008-0300-7
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发表时间：
2009-02-01
期刊：
影响因子：
1.6
通讯作者：
Liu, Jin-Hua
中科院分区：
文献类型：
--
作者：
Pu, Juan;Liu, Qin-Fang;Liu, Jin-Hua
H3亚型流感病毒在禽类和哺乳动物宿主中的广泛分布和流行构成了对人类和兽医健康的全球威胁。本研究对2004年至2005年从中国北部地区家鸭中分离到的6株H3N8流感病毒进行了基因和系统发育分析。序列分析表明，6个H3N8分离株的HA、NA和M基因与曾在中国北部马群中暴发的马/吉林/1/89(H3N8)病毒的HA、NA和M基因具有密切的亲缘关系。这些病毒的PB2和PA基因与目前在该地区流行的高致病性H5N1禽流感病毒具有最高的相似性。这些发现强调了在该地区监测禽流感病毒对于了解具有大流行潜力的新型重组体的起源和紧急情况的重要性。
The broad distribution and prevalence of H3 subtype influenza viruses in avian and mammalian hosts constitutes a global threat to both human and veterinary health. In this present study, six H3N8 influenza viruses isolated from domestic ducks during 2004-2005 in northern China were genetically and phylogenetically characterized. Sequence analysis showed that HA, NA, and M genes of all the six H3N8 isolates had a close relationship with those of Equine/Jilin/1/89 (H3N8) virus, which once caused outbreak in equine populations in northern China. The PB2 and PA genes of the viruses possessed the highest similarities with highly pathogenic avian H5N1 influenza viruses currently circulating in this region. These findings emphasize the importance of avian influenza virus surveillance in this region for understanding the genesis and emergency of novel reassortants with pandemic potential.