Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population
Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population
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DOI：
10.1016/j.bbrc.2005.02.101
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发表时间：
2005-04-22
影响因子：
3.1
通讯作者：
Keicho, N
中科院分区：
文献类型：
--
作者：
Hamano, E;Hijikata, M;Keicho, N
我们假设I型干扰素诱导的宿主抗病毒基因可能影响严重急性呼吸系统综合征（SARS）的自然病程。我们分析了44名越南SARS患者的2',5'-寡聚腺苷酸合成酶I (OAS-1)，黏液病毒抗性a （MxA）和双链rna依赖性蛋白激酶的单核苷酸多态性（snp）。OAS-1基因外显子3非同义A/G SNP的G等位基因与SARS存在相关性（p = 0.0090）。OAS-1外显子3的g等位基因和外显子6的g等位基因处于强连锁不平衡状态，它们都与SARS感染有关。MxA基因启动子-88位GG基因型和G/T SNP等位基因在低氧血症组的出现频率高于非低氧血症组（p = 0.0195）。我们的研究结果表明，两个ifn诱导基因OAS-1和MxA的多态性可能在各个水平上影响SARS的易感性和进展。2005爱思唯尔公司版权所有。
We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2',5'-oligoadenylate synthetase I (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p = 0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p = 0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level. 2005 Elsevier Inc. All rights reserved.