TRANSITION-METAL-CATALYZED ANNELATION REACTIONS .5. PALLADIUM-CATALYZED C-H ACTIVATION OF TERT-BUTYL GROUPS - A SIMPLE SYNTHESIS OF 1,2-DIHYDROCYCLOBUTABENZENE DERIVATIVES
TRANSITION-METAL-CATALYZED ANNELATION REACTIONS .5. PALLADIUM-CATALYZED C-H ACTIVATION OF TERT-BUTYL GROUPS - A SIMPLE SYNTHESIS OF 1,2-DIHYDROCYCLOBUTABENZENE DERIVATIVES
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DOI：
10.1002/anie.199401031
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发表时间：
1994-01-17
期刊：
影响因子：
--
通讯作者：
DYKER, G
中科院分区：
文献类型：
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作者：
DYKER, G
通常选择金属化反应来活化C-H键，否则C-H键将太不反应。在这方面，应特别提及催化反应中的过渡金属。尽管钯催化的CH在sp2碳中心的活化现在被确定为烯烃和芳烃的选择性官能化的关键步骤，但在sp3杂化碳原子处的这种反应，这可能会开辟许多合成的可能性，几乎没有被检查。[21本文报道了一种新的多米诺偶联反应，首次发现了钯催化的CH在叔丁基上的活化反应。
Metalation reactions are often chosen to activate C-H bonds which would otherwise be too unreactive. In this context special mention should be made of transition metals in catalytic reactions. Whereas the palladium catalyzed CH activation at sp2 carbon centers is now established as a key step in the selective functionalization of alkenes and arenes,"] such reactions at sp3 hybridized carbon atoms, which could open up many synthetic possibilities, have hardly been examined.[21 A new domino coupling reaction is described here in the course of which a palladium-catalyzed CH activation at a tert-butyl group is observed for the first time.