AMPHETAMINE AND COCAINE INDUCE DRUG-SPECIFIC ACTIVATION OF THE C-FOS GENE IN STRIOSOME MATRIX COMPARTMENTS AND LIMBIC SUBDIVISIONS OF THE STRIATUM
AMPHETAMINE AND COCAINE INDUCE DRUG-SPECIFIC ACTIVATION OF THE C-FOS GENE IN STRIOSOME MATRIX COMPARTMENTS AND LIMBIC SUBDIVISIONS OF THE STRIATUM
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DOI：
10.1073/pnas.87.17.6912
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发表时间：
1990-09-01
影响因子：
11.1
通讯作者：
ROBERTSON, HA
中科院分区：
文献类型：
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作者：
GRAYBIEL, AM;MORATALLA, R;ROBERTSON, HA
安非他明和可卡因是兴奋剂药物，作用于中枢单胺能神经元，产生急性精神兴奋和持久的行为影响，包括成瘾和精神病。在这里，我们报告说，单剂量的这些药物诱导快速表达的核原癌基因c-fos在前脑，特别是在纹状体，锥体外系结构牵连成瘾和长期药物引起的运动功能的变化。这两种药物诱导的c-fos的表达在纹状体基质室和边缘的纹状体分区的模式截然不同，其效果是非常不同的，虽然都是敏感的多巴胺受体阻滞剂。我们认为，不同的激活立即早期基因的精神兴奋剂可能是早期的一个步骤，在药物特异性分子级联反应，促进急性和持久的精神兴奋剂诱导的行为变化。
Amphetmaine and cocaine are stimulant drugs that act on central monoaminergic neurons to produce both acute psychomotor activation and long-lasting behavioral effects including addiction and psychosis. Here we report that single doses of these drugs induce rapid expression of the nuclear proto-oncogene c-fos in the forebrain and particularly in the striatum, an extrapyramidal structure implicated in addiction and in long-term drug-induced changes in motor function. The two drugs induce strikingly different patterns of c-fos expression in the striosome-matrix compartments and limbic subdivisions of the striatum, and their effects are pharmacologically distinct, although both are sensitive to dopamine receptor blockade. We propose that different activation of immediate-early genes by psychostimulants may be an early step in drug-specific molecular cascades contributing to acute and long-lasting psychostimulant-induced changes in behavior.