Autologous fat transplants influence compensatory white adipose tissue mass increases after lipectomy.
Autologous fat transplants influence compensatory white adipose tissue mass increases after lipectomy.
复制标题
自体脂肪移植影响脂肪切除术后白色脂肪组织质量的代偿性增加。
DOI：
10.1152/ajpregu.00476.2003
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Bartness,TimothyJ
中科院分区：
文献类型：
--
作者：
Lacy,EvaL;Bartness,TimothyJ
Direct tests of the hypothesized total body fat regulatory system have been accomplished by partial surgical lipectomy. This usually results in the restoration of the lipid deficit through compensatory increases in nonexcised white adipose tissue (WAT) masses of ground squirrels, laboratory rats, and mice, as well as Siberian and Syrian hamsters. We challenged this hypothesized total body fat regulatory system by testing the response of Siberian hamsters to1) lipid deficits [lipectomy; primarily bilateral epididymal WAT (EWAT) removal],2) lipid surfeits (addition of donor EWAT with no lipectomy),3) no net change in lipid [EWAT or inguinal WAT (IWAT) lipectomy with the excised fat replaced to a new location (autologous)],4) lipectomy with the same pad (EWAT lipectomy only) added from a sibling (nonautologous), and5) sham surgeries for each treatment. Food intake generally was not affected. Body mass was not affected across all treatments. Grafts ∼3 mo later had normal appearance both macro- and microscopically and were revascularized. The normal lipectomy-induced compensatory increases in nonexcised WAT masses surprisingly were exaggerated with autologous EWAT transplants, but not for autologous IWAT or nonautologous EWAT transplants. There was no compensatory decrease in native WAT masses with nonautologous EWAT additions. Collectively, only lipectomy triggered reparation of the lipid deficit, but the other manipulations did not, suggesting a system biased toward rectifying decreases in lipid or an inability of the hypothesized total body fat regulatory system to recognize WAT transplants.
