Dynamics of p53: A Master Decider of Cell Fate.
Dynamics of p53: A Master Decider of Cell Fate.
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DOI：
10.3390/genes8020066
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发表时间：
2017-02-09
期刊：
影响因子：
3.5
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Luo Q;Beaver JM;Liu Y;Zhang Z
细胞应激诱导的时间变化--即动力学--典型的例证是P53的动力学，它是决定细胞命运的主要因素。P53的动态变化最初被认为是P53蛋白水平的变化。然而，越来越多的研究表明，P53的动态也表现在P53蛋白的活性、空间位置和翻译后修饰的变化，以及所有P53动态特征之间的相互作用。这些在决定细胞命运的具体结果方面是必不可少的。在这篇综述中，我们讨论了P53动力学的多方面特征的重要性及其在细胞命运决定过程中的作用，以及它们在基于P53的癌症治疗中的潜在应用。该综述对P53信号通路及其在开发基于P53的癌症治疗新策略方面的潜力提供了新的见解。
Cellular stress-induced temporal alterations—i.e., dynamics—are typically exemplified by the dynamics of p53 that serve as a master to determine cell fate. p53 dynamics were initially identified as the variations of p53 protein levels. However, a growing number of studies have shown that p53 dynamics are also manifested in variations in the activity, spatial location, and posttranslational modifications of p53 proteins, as well as the interplay among all p53 dynamical features. These are essential in determining a specific outcome of cell fate. In this review, we discuss the importance of the multifaceted features of p53 dynamics and their roles in the cell fate decision process, as well as their potential applications in p53-based cancer therapy. The review provides new insights into p53 signaling pathways and their potentials in the development of new strategies in p53-based cancer therapy.