VAMP2 is expressed in myogenic cells during rat development
VAMP2 is expressed in myogenic cells during rat development
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DOI：
10.1002/dvdy.21596
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发表时间：
2008-07-01
影响因子：
2.5
通讯作者：
Yorifuji, Hiroshi
中科院分区：
文献类型：
--
作者：
Tajika, Yuki;Murakami, Tohru;Yorifuji, Hiroshi
囊泡相关膜蛋白2 （VAMP2）是SNARE蛋白家族的一员，可调节细胞内囊泡融合过程。本研究探讨了VAMP2在大鼠胚胎中的发育表达。在躯干中，VAMP2主要在胚胎日的心脏中发现(E) 10。在E12.5上，VAMP2在神经纤维、体和心脏中表达。有时，背内侧唇的上皮细胞和肌组的细长成肌细胞表达VAMP2阳性。在E16.5， VAMP2在心脏、神经纤维和骨骼肌中表达。在骨骼肌中，多核肌管VAMP2阳性。在头部，肌肉来源于体裂肌和非体裂肌，在E16.5上，在外在眼肌和咬肌的肌管中发现了VAMP2。这些发现表明VAMP2参与了体裂和非体裂起源的骨骼肌的发育。
Vesicle-associated membrane protein 2 (VAMP2) is a member of the SNARE family of proteins that regulate the intracellular vesicle fusion process. This study investigated the developmental expression of VAMP2 in the rat embryo. In the trunk, VAMP2 was primarily found in the heart on embryonic day (E) 10. On E12.5, VAMP2 expression was found in nerve fibers, somites, and heart. In somites, epithelial cells in the dorsomedial lip, and elongated myoblasts in myotome were positive for VAMP2. On E16.5, VAMP2 was expressed in the heart, nerve fibers, and skeletal muscles. In skeletal muscles, multinuclear myotubes were positive for VAMP2. In the head, where muscles are derived both from somitic and non-somitic origin, VAMP2 was found in myotubes of the extrinsic ocular muscles and masseter muscle on E16.5. These findings suggest the involvement of VAMP2 in the development of skeletal muscles of somitic and non-somitic origins.