Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction.
Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction.
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DOI：
10.1146/annurev.iy.10.040192.002001
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发表时间：
1992
影响因子：
29.7
通讯作者：
and A S Rosenberg;A. Singer
中科院分区：
文献类型：
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作者：
and A S Rosenberg;A. Singer
同种异体组织移植的排斥反应源于T细胞对供者移植物细胞表达的组织相容性抗原的识别。本文综述了T细胞的表型、特异性和功能，以及宿主T细胞被移植物内的细胞群激活或无反应的免疫机制。我们回顾了跨越有限的I类和II类主要组织相容性差异的排斥反应的细胞基础，以及排斥反应本身的特异性。
Rejection of transplanted tissue allografts results from T-cell recognition of histocompatibility antigens expressed by cells of the donor graft. This review focuses on the phenotype, specificity, and function of the T cells mediating rejection responses against skin allografts, and on the immune mechanisms by which host T cells are either activated or rendered non-responsive by cellular populations within the graft. We review the cellular basis for rejection responses across limited class-I and class-II major histocompatibility differences, as well as the specificity of the rejection response itself.