Proteomic responses of skeletal and cardiac muscle to exercise.
Proteomic responses of skeletal and cardiac muscle to exercise.
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骨骼肌和心肌对运动的蛋白质组学反应。
DOI：
10.1586/epr.11.17
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发表时间：
2011-06
影响因子：
3.4
通讯作者：
Hoffman EP
中科院分区：
文献类型：
--
作者：
Burniston JG;Hoffman EP
定期锻炼可有效预防慢性病，并降低患有高血压和血脂异常等危险因素的个体的死亡风险。因此，对运动的分子反应的了解为解释疾病研究提供了有价值的对比，并可以突出新的治疗靶点。虽然运动是一种日常体验，可以用简单的术语来概念化，但运动是一种复杂的生理现象，运动反应的研究需要复杂的分析技术和运动刺激的仔细标准化。运动的蛋白质组学研究还处于起步阶段，但将功能变化与蛋白质表达和翻译后修饰的全面变化联系起来的能力为推进生理学带来了巨大的希望。这篇综述重点介绍了最近研究运动对骨骼和心肌的影响的开创性工作，这些工作揭示了体育活动益处的新机制。
Regular exercise is effective in the prevention of chronic diseases and confers a lower risk of death in individuals displaying risk factors such as hypertension and dyslipidaemia. Thus, knowledge of the molecular responses to exercise provides a valuable contrast for interpreting investigations of disease and can highlight novel therapeutic targets. While exercise is an everyday experience and can be conceptualized in simple terms, exercise is a complex physiological phenomena and investigation of exercise responses requires sophisticated analytical techniques and careful standardization of the exercise stimulus. Proteomic investigation of exercise is in its infancy but the ability to link changes in function with comprehensive changes in protein expression and post-translational modification holds great promise for advancing physiology. This review highlights recent pioneering work investigating the effects of exercise in skeletal and cardiac muscle that has uncovered novel mechanisms underling the benefits of physical activity.