The role of MT+/V5 during biological motion perception in Asperger Syndrome: An fMRI study
The role of MT+/V5 during biological motion perception in Asperger Syndrome: An fMRI study
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DOI：
10.1016/j.rasd.2006.07.002
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发表时间：
2007-01-01
影响因子：
2.5
通讯作者：
Williams, Steve C. R.
中科院分区：
文献类型：
--
作者：
Herrington, John D.;Baron-Cohen, Simon;Williams, Steve C. R.
自闭症谱系中的一种病症，其特征在于使用社会线索来推断心理状态信息的能力的缺陷。很少有研究探讨这些缺陷是否可以理解为视觉信息处理的差异。本研究采用功能性磁共振成像来检查AS患者在执行通常导致自动解释人类运动的任务时大脑活动的差异。尽管行为表现相似，但AS组（相对于对照组）在下、中、上级颞区（包括MT+/V5的人类类似物）的活动显著减少。这些数据表明，AS与视觉呈现的社会线索的感知过程中的大脑活动的独特模式有关。(C)2006爱思唯尔有限公司保留所有权利。
Asperger Syndrome (AS), a condition on the autistic spectrum, is characterized by deficits in the ability to use social cues to infer mental state information. Few studies have examined whether these deficits might be understood in terms of differences in visual information processing. The present study employed functional magnetic resonance imaging to examine differences in brain activity among individuals with AS while performing a task that typically leads to the automatic interpretation of human movement. Despite similar behavioural performance, significantly less activity was found for the AS group (relative to a control group) in inferior, middle and superior temporal regions, including the human analogue of MT+/V5. These data suggest that AS is associated with unique patterns of brain activity during the perception of visually presented social cues. (C) 2006 Elsevier Ltd. All rights reserved.