Aplastic anemia complicating systemic lupus erythematosus – report of a case and review of the literature
Aplastic anemia complicating systemic lupus erythematosus – report of a case and review of the literature
复制标题
再生障碍性贫血并发系统性红斑狼疮一例报告并文献复习
DOI：
10.1007/s00296-002-0254-3
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发表时间：
2002
影响因子：
4
通讯作者：
Mathew Thomas
中科院分区：
文献类型：
--
作者：
K. Pavithran;N. Raji;Mathew Thomas
抽象的。再生障碍性贫血是系统性红斑狼疮 (SLE) 的一个非常不寻常的特征。一名32岁的女士出现全身性紫癜病变，被诊断为免疫性血小板减少性紫癜。十四个月后，她出现进行性全血细胞减少症、小关节关节炎和口腔溃疡。调查证实系统性红斑狼疮合并再生障碍性贫血。高剂量甲基泼尼松龙治疗未能成功控制全血细胞减少症。她的病情呈进行性发展，并因败血症死亡。尽管全血细胞减少症在 SLE 中很常见，但对于所有持续性全血细胞减少症病例都应进行骨髓检查，以排除骨髓再生障碍。这将有助于调整更具侵袭性的免疫抑制剂的治疗方案。
Abstract. Aplastic anemia is a very unusual feature of systemic lupus erythematosus (SLE). A 32-year-old lady presented with generalized purpuric lesions and was diagnosed as having immune thrombocytopenic purpura. Fourteen months later, she developed progressive pancytopenia, arthritis of small joints, and oral ulcers. Investigations confirmed SLE with aplastic anemia. High-dose methylprednisolone therapy had been unsuccessful in controlling the pancytopenia. She had a progressive course and died due to septicemia. Even though pancytopenia is common in SLE, a bone marrow examination should be done in all cases of persistent pancytopenia to exclude bone marrow aplasia. This will help in tailoring the treatment with more aggressive immunosuppressants.