THE LEWIS SYSTEM AND KIDNEY TRANSPLANTATION
THE LEWIS SYSTEM AND KIDNEY TRANSPLANTATION
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刘易斯系统和肾移植
作者：
R. Oriol;G. Opelz;C. Chun;P. Terasaki
在1,300例北美移植中发现刘易斯抗原对尸体肾移植存活率有显著影响。Lewis阴性受体的移植物存活率比Lewis阳性受体低8%（P = 0.05）。刘易斯抗原的这种作用在由年龄、种族或移植中心确定的高失败风险患者中增强。在30岁以上的患者中，刘易斯的疗效为14（P = 0.07），非高加索人12%（P = 0.07），在<50%的中心进行的所有移植物中，1年移植物总存活率为12%（P = 0.03），而在接受移植的非高加索人中，总移植物存活率<50%的中心为18%（P = 0.01）。这些数据证实了先前关于刘易斯作为肾移植中的组织相容性系统的作用的结果;此外，它们表明刘易斯的影响在高风险患者中更大。
A significant effect of Lewis antigens on cadaver kidney graft survival was found in 1,300 North American transplants. Lewis-negative recipients had a graft survival rate that was 8% lower than that of Lewis-positive recipients (P = 0.05). This effect of Lewis antigens was enhanced in patients at a high failure risk as determined by age, race, or transplant center. In patients older than 30 years, the effect of Lewis was 14% (P = 0.07), in non-Caucasians 12% (P = 0.07), in all grafts performed at centers with <50% overall 1-year graft survival 12% (P = 0.03), and in non-Caucasians that received transplants in centers with <50% overall graft survival it was 18% (P = 0.01). These data confirm previous results on the role of Lewis as a histocompatibility system in renal transplantation; furthermore, they demonstrate that the influence of Lewis is larger in patients at high risk.