Markers of central nervous system glia and neurons in vivo during normal and pathological conditions.
Markers of central nervous system glia and neurons in vivo during normal and pathological conditions.
复制标题
DOI：
10.1007/978-3-662-09525-6_6
复制
发表时间：
2002
影响因子：
--
通讯作者：
J. Redwine;C. Evans
中科院分区：
文献类型：
--
作者：
J. Redwine;C. Evans
Cell markers are valuable tools for examining the function of cells in normal conditions as well as during disease and repair processes. In fact, our understanding of the cell types that make up the central nervous system (CNS) is very much shaped by the markers available to identify them. CNS cell types were originally identified by morphology. The discovery of various proteins specific to certain cells led to the production of cell-type-specific antibodies that have been used to identify cells in situ. An ideal marker is specific to a given cell type in normal conditions and/or during conditions involving injury or disease. As simple as these criteria sound, they are not easy to fulfill. Markers can be expressed on more that one cell type. Astrocytes and olfactory-tract-ensheathing glia both express glial fibrillary acidic protein (GFAP), even though they have clear phe-notypic, anatomical, and functional differences (Ramon-Cueto and Valverde 1995). Also, a marker that is specific for a given cell type in normal conditions can be induced or up-regulated on other cell types during conditions such as inflammation, disease, or injury. Therefore cell type markers alone do not always conclusively identify a cell type.
