Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema:: ISAAC
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema:: ISAAC
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DOI：
10.1016/s0140-6736(97)07302-9
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发表时间：
1998-04-25
期刊：
影响因子：
168.9
通讯作者：
Williams, HC
中科院分区：
文献类型：
--
作者：
Beasley, R;Keil, U;Williams, HC
背景
为了更好地了解儿童哮喘及其他过敏性疾病的全球流行病学情况，提出新的假设，并评估现有关于可能病因的假设，需要对这些疾病的患病率进行系统性的国际比较。我们对全球范围内哮喘、过敏性鼻结膜炎和特应性湿疹的患病率进行了调查。
方法
我们对56个国家的155个协作中心的463801名13 - 14岁儿童进行了研究。儿童通过一页问卷自我报告这三种特应性疾病的症状。在42个国家的99个中心，还对304796名儿童使用了视频哮喘问卷。
结果
我们发现不同中心之间哮喘、过敏性鼻结膜炎和特应性湿疹症状的患病率存在20倍到60倍的差异，不同疾病在第10百分位数和第90百分位数之间存在4倍到12倍的差异。就哮喘症状而言，12个月患病率最高的来自英国、澳大利亚、新西兰和爱尔兰共和国的中心，其次是北美洲、中美洲和南美洲的大多数中心；患病率最低的来自几个东欧国家、印度尼西亚、希腊、中国、中国台湾地区、乌兹别克斯坦、印度和埃塞俄比亚的中心。对于过敏性鼻结膜炎，患病率最高的中心分布在世界各地。患病率最低的中心与哮喘症状患病率最低的中心相似。对于特应性湿疹，患病率最高的来自分布各地的中心，包括一些来自斯堪的纳维亚半岛和非洲的中心，这些中心不在哮喘患病率最高的中心之列；特应性湿疹患病率最低的中心情况与哮喘症状相似。
解释
全球不同中心之间哮喘、过敏性鼻结膜炎和特应性湿疹症状的患病率差异显著。这些发现将为进一步研究潜在导致这些国际差异模式的因素奠定基础。
Background Systematic international comparisons of the prevalences of asthma and other allergic disorders in children are needed for better understanding of their global epidemiology, to generate new hypotheses, and to assess existing hypotheses of possible causes. We investigated worldwide prevalence of asthma, allergic rhinoconjunctivitis, and atopic eczema.Methods We studied 463 801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304 796 children.Findings We found differences of between 20-fold and 60-fold between centres in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema, with four-fold to 12-fold variations between the 10th and 90th percentiles for the different disorders. For asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia. For allergic rhinoconjunctivitis, the centres with the highest prevalences were scattered across the world. The centres with the lowest prevalences were similar to those for asthma symptoms. For atopic eczema, the highest prevalences came from scattered centres, including some from Scandinavia and Africa that were not among centres with the highest asthma prevalences; the lowest prevalence rates of atopic eczema were similar in centres, as for asthma symptoms.Interpretation The variation in the prevalences of asthma, allergic rhinoconjunctivitis, and atopic-eczema symptoms is striking between different centres throughout the world. These findings will form the basis of further studies to investigate factors that potentially lead to these international patterns.