Case of solitary pulmonary capillary hemangioma: Pathological features based on frozen section analysis
Case of solitary pulmonary capillary hemangioma: Pathological features based on frozen section analysis
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DOI：
10.1111/pin.12120
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发表时间：
2013-12-01
影响因子：
2.2
通讯作者：
Masuda, Munetaka
中科院分区：
文献类型：
--
作者：
Isaka, Tetsuya;Yokose, Tomoyuki;Masuda, Munetaka
孤立性肺毛细血管瘤（SPCH）是一种罕见的良性肺肿瘤，必须与小而早期的肺癌相鉴别。在这里，我们报告一例SPCH，我们对其进行了冷冻切片诊断。患者为一名55岁的日本妇女。术前5年，计算机断层扫描发现左侧下叶后基底段混合性磨玻璃影（S10）。因毛玻璃影内肿瘤密度略有增加，行视频辅助胸外科楔形切除。冰冻切片诊断为良性肿瘤，无非典型上皮细胞增生。肿瘤肺泡腔狭窄，肺泡隔增厚，与正常肺组织边界清晰。增生的管腔大小不一，内衬单层扁平细胞。术后石蜡切片免疫组化染色显示，肺泡间隔增厚是毛细血管增生所致，其中扁平细胞CD31、CD34阳性，podoplanin阴性；诊断为SPCH。在此，我们结合本病例讨论冷冻切片上SPCH的病理特征，并回顾以往的相关报道。
Solitary pulmonary capillary hemangioma (SPCH) is a rare benign lung tumor that must be distinguished from small and early lung cancers. Here, we report a case of SPCH for which we performed frozen section diagnosis. The patient was a 55-year-old Japanese woman. Five years before the operation, mixed ground-glass opacity was detected by computed tomography in the left posterior basal segment of the lower lobe (S10). Because the interior tumor density of the ground-glass opacity increased slightly, video-assisted thoracic surgery wedge resection was performed. Frozen section diagnosis revealed a benign tumor without proliferation of atypical epithelial cells. The tumor had narrow alveolar lumens, thickened alveolar septa and a clear boundary separating it from normal lung tissue. The proliferated lumens varied in size and were lined with single layers of flat cells. After the operation, immunohistochemical staining of a paraffin section revealed that the thickened alveolar septa resulted from the proliferation of capillary vessels, the flat cells of which were positive for CD31 and CD34 and negative for podoplanin; the tumor was diagnosed as SPCH. Here, we discuss the pathological features of SPCH on frozen sections with reference to this case and review previous related reports.