Common and distinct modulation of electrophysiological indices of feedback processing by autistic and psychopathic traits.
Common and distinct modulation of electrophysiological indices of feedback processing by autistic and psychopathic traits.
复制标题
自闭症和精神病性状对反馈处理的电生理指数的常见和独特的调节。
DOI：
10.1080/17470919.2015.1108223
复制
发表时间：
2016
影响因子：
2
通讯作者：
McPartland JC
中科院分区：
文献类型：
--
作者：
Carter Leno V;Naples A;Cox A;Rutherford H;McPartland JC
自闭症谱系障碍（ASD）和精神病都以社交功能障碍为主要特征；重叠的表型特征可能反映了普通脑机制的功能改变。目前的研究在典型发育成人样本（N=31, 11名男性，18-52岁）中检测了自闭症与精神病特征对社会和非社会反馈的神经反应调节程度。当参与者完成一项行为任务并收到任务表现的反馈时，事件相关电位被记录下来。自闭症和精神病特征都与反馈处理的神经相关改变有关。对特定形式的反馈（社交的、非社交的、积极的、消极的）的敏感性在两种特征之间是不同的。自闭症特征与对社会反馈的敏感度降低有关。相反，精神病态特征的反社会领域与反馈敏感性的总体下降有关，人际操纵领域与保留积极反馈的加工有关。结果表明，在反馈处理的特定机制中存在明显的变化，这可能是社会行为中类似困难的基础。
Both autism spectrum disorder (ASD) and psychopathy are primarily characterized by social dysfunction; overlapping phenotypic features may reflect altered function in common brain mechanisms. The current study examined the degree to which neural response to social and non-social feedback is modulated by autistic versus psychopathic traits in a sample of typically-developing adults (N=31, 11 males, 18–52 years). Event-related potentials were recorded whilst participants completed a behavioral task and received feedback on task performance. Both autistic and psychopathic traits were associated with alterations in the neural correlates of feedback processing. Sensitivity to specific forms of feedback (social, non-social, positively-valenced, negatively-valenced) differed between the two traits. Autistic traits were associated with decreased sensitivity to social feedback. In contrast, the antisocial domain of psychopathic traits was associated with an overall decrease in sensitivity to feedback, and the interpersonal manipulation domain was associated with preserved processing of positively-valenced feedback. Results suggest distinct alterations within specific mechanisms of feedback processing may underlie similar difficulties in social behavior.