CALCIUM, IRON, COPPER, BORON, COLLAGEN, AND DENSITY CHANGES IN BONE WITH AGING IN C57BL/6J MALE-MICE
CALCIUM, IRON, COPPER, BORON, COLLAGEN, AND DENSITY CHANGES IN BONE WITH AGING IN C57BL/6J MALE-MICE
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DOI：
10.1016/0531-5565(90)90035-z
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发表时间：
1990-01-01
影响因子：
3.9
通讯作者：
ARMSTRONG, T
中科院分区：
文献类型：
--
作者：
MASSIE, HR;AIELLO, VR;ARMSTRONG, T
老年C57 BL/6 J雄性小鼠的X射线显示脊柱变形。发现骨密度在76至517日龄之间增加，在685日龄之后降低。股骨硼含量随增龄下降9%，但下降不显著。钙在76至198日龄之间增加，但在200至1000日龄之间下降了36%。铁在1000天龄时增加了207%。铜在76至198日龄之间下降，但在200至1000日龄之间增加了61%。骨胶原羟脯氨酸和脯氨酸含量下降17.4%，1000日龄。因此，随着年龄的增长，最大的单一变化是骨骼中的铁含量。发现几种相关性与动物的年龄无关。骨密度与骨钙、骨胶原相关。铁与钙、胶原呈负相关。钙和胶原蛋白含量无关。骨密度和铁也令人惊讶地无关。一个可能的解释，这一观察。铜与骨钙、骨密度、胶原含量呈负相关。因此，过量的铜是与骨大小和密度降低相关的最重要的因素。
X-rays of old C57BL/6J male mice showed deformed vertebral columns. Bone density was found to increase between 76 and 517 days of age and to decrease after 685 days of age. The boron content of femurs declined by 9% with aging but the decrease was not significant. Calcium increased between 76 and 198 days of age but declined by 36% between 200 and 1000 days of age. Iron increased by 207% by 1000 days of age. Copper declined between 76 and 198 days of age but incresed by 61% between 200 and 1000 days of age. Bone collagen as indicated by hydroxyproline and proline content decreased 17.4% by 1000 days of age. The largest single change with aging was, therefore, in the iron content of bone. Several correlations were found to be independent of the age of the animals. Bone density was correlated with bone calcium and collagen. Iron was negatively correlated with calcium and collagen. Calcium and collagen content were unrelated. Bone density and iron were also surprisingly unrelated. A possible explanation for this observation is given. Copper was negatively correlated with bone calcium, bone density, and collagen content. Excess copper was, therefore, the single most important factor associated with decreasing bone size and density.