Trace Conditioning in Drosophila Induces Associative Plasticity in Mushroom Body Kenyon Cells and Dopaminergic Neurons.
Trace Conditioning in Drosophila Induces Associative Plasticity in Mushroom Body Kenyon Cells and Dopaminergic Neurons.
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DOI：
10.3389/fncir.2017.00042
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发表时间：
2017
影响因子：
3.5
通讯作者：
Szyszka P
中科院分区：
文献类型：
--
作者：
Dylla KV;Raiser G;Galizia CG;Szyszka P
多巴胺能神经元（DAN）在联想学习过程中发出惩罚和奖励信号。在哺乳动物中，DAN显示出与经典条件反射期间预测和实际强化（预测错误）之间的差异相关的关联可塑性。同样在昆虫中，如果蝇，DAN显示出关联可塑性，然而，了解较少。在这里，我们研究关联可塑性在DAN和他们的突触合作伙伴，肯扬细胞（KC）在蘑菇体（MB），而训练果蝇联想到一个气味与时间上分离的电击（痕迹条件）。在大多数MB车厢的DAN加强了他们的反应条件气味相对于未经训练的动物。这种反应的可塑性保持了气味和冲击引起的空间反应模式之间的初始相似程度，这在未经训练的动物中有所下降。与DAN相反，KCs（“/”型）相对于未经训练的动物降低了它们对条件气味剂的反应。我们没有发现任何证据的预测错误编码的DAN在空调。相反，我们的数据支持这一假设，即DAN可塑性编码条件诱导的气味的预测能力的变化。
Dopaminergic neurons (DANs) signal punishment and reward during associative learning. In mammals, DANs show associative plasticity that correlates with the discrepancy between predicted and actual reinforcement (prediction error) during classical conditioning. Also in insects, such as Drosophila, DANs show associative plasticity that is, however, less understood. Here, we study associative plasticity in DANs and their synaptic partners, the Kenyon cells (KCs) in the mushroom bodies (MBs), while training Drosophila to associate an odorant with a temporally separated electric shock (trace conditioning). In most MB compartments DANs strengthened their responses to the conditioned odorant relative to untrained animals. This response plasticity preserved the initial degree of similarity between the odorant- and the shock-induced spatial response patterns, which decreased in untrained animals. Contrary to DANs, KCs (α'/β'-type) decreased their responses to the conditioned odorant relative to untrained animals. We found no evidence for prediction error coding by DANs during conditioning. Rather, our data supports the hypothesis that DAN plasticity encodes conditioning-induced changes in the odorant's predictive power.