Muscle regeneration by bone marrow derived myogenic progenitors
Muscle regeneration by bone marrow derived myogenic progenitors
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DOI：
10.1126/science.279.5356.1528
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发表时间：
1998-03-06
期刊：
影响因子：
56.9
通讯作者：
Mavilio, F
中科院分区：
文献类型：
--
作者：
Ferrari, G;Cusella-De Angelis, G;Mavilio, F
骨骼肌的生长和修复通常由肌纤维周围的卫星细胞介导。然而，在再生肌肉中，肌原性前体细胞的数量超过了常驻卫星细胞的数量，这意味着来自其他来源的未分化祖细胞的迁移或募集。将基因标记的骨髓移植到免疫缺陷小鼠体内，揭示了骨髓源性细胞迁移到诱导的肌肉变性区域，经历肌源性分化，并参与受损纤维的再生。基因修饰的骨髓源性肌源性祖细胞可能用于将治疗基因靶向肌肉组织，为治疗肌营养不良症提供了另一种策略。
Growth and repair of skeletal muscle are normally mediated by the satellite cells that surround muscle fibers, In regenerating muscle, however, the number of myogenic precursors exceeds that of resident satellite cells, implying migration or recruitment of undifferentiated progenitors from other sources. Transplantation of genetically marked bone marrow into Immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers, Genetically modified, marrow-derived myogenic progenitors could potentially be used to target therapeutic genes to muscle tissue, providing an alternative strategy for treatment of muscular dystrophies.