Quantitative analysis of viral persistence and transient viral load rebound from HIV clinical data.
Quantitative analysis of viral persistence and transient viral load rebound from HIV clinical data.
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根据 HIV 临床数据对病毒持久性和短暂病毒载量反弹进行定量分析。
DOI：
10.1109/iembs.2011.6090599
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Zurakowski,Ryan
中科院分区：
文献类型：
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作者：
Luo,Rutao;Piovoso,MichaelJ;Zurakowski,Ryan
高活性抗逆转录病毒治疗（HAART）抑制HIV RNA病毒载量低于检测限制的许多患者。然而，临床数据表明，即使在7年未检测到病毒的患者中，HAART也不能根除艾滋病毒。一个可能的原因是在静止记忆CD4+T细胞[2]中存在一个稳定的、半衰期长的静止潜伏库。在本文中，我们提出了一个具有稳定潜伏库恒定贡献的数学模型，并通过AutoVac HAART中断研究[3]中的一个患者数据确定了该常数。在HAART成功控制病毒的情况下，许多患者血浆病毒RNA也有短暂反弹（病毒突变）。潜伏感染细胞的激活可以解释这些病毒载量的短暂反弹。在临床实验数据的基础上，对储层活化的定量分析很少。在这里，我们通过与时间无关的激活率来模拟储层的激活动力学，并使用AutoVac HAART中断研究[3]的临床数据来估计该速率。
Highly active antiretroviral therapy (HAART) suppresses HIV RNA viral load below the limit of detection for many patients. However, clinical data demonstrates that the HIV virus is not eradicated by HAART, even in patients who have had no detectable virus for 7 years [1]. One possible reason is that a stable resting latent reservoir with a long half-life exists in resting memory CD4+T cells [2]. In this paper, we propose a mathematical model with a constant contribution of a stable latent reservoir and identified this constant by using one patient's data from AutoVac HAART interruption study [3]. Many patients also have transient rebounds of plasma viral RNA (viral blips) under otherwise successful control of the virus by HAART. Activation of latently infected cells can explain these transient rebounds of viral load. Little quantitative analysis about the activation of reservoir has been done based on any clinical experiment data. Here, we model the activation dynamics of the reservoir by a time-independent activation rate and estimate this rate by using the clinical data from the AutoVac HAART interruption study [3].