Association of muscular strength with incidence of metabolic syndrome in men
Association of muscular strength with incidence of metabolic syndrome in men
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DOI：
10.1249/01.mss.0000175865.17614.74
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发表时间：
2005-11-01
期刊：
影响因子：
--
通讯作者：
Blair, SN
中科院分区：
文献类型：
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作者：
Jurca, R;Lamonte, MJ;Blair, SN
目的：探讨肌肉力量与代谢综合征发病率之间的关系。方法：参与者是3233名最初没有代谢综合征的男性（20-80岁），他们在1980年至2003年间进行了两次或两次以上的临床检查，包括基线肌肉力量和心肺健康评估。根据NCEP-ATP III标准定义代谢综合征。肌肉力量是通过结合体重调整的腿部和卧推的一次重复最大测量来量化的。采用最大跑步机试验评价心肺功能。结果：在平均6.7 +/- 5.2年的随访期间，共有480名男性出现代谢综合征。在调整年龄的Cox回归分析中，代谢综合征与肌肉力量增量类别相关的风险比（95%置信区间）分别为1.00（参考）、0.88（0.69-1.12）、0.77（0.60-0.98）和0.54(0.42-0.71)（线性趋势P < 0.0001）。在调整吸烟、饮酒、基线代谢综合征危险因素数量、糖尿病家族史、高血压和过早冠状动脉疾病后，这种反向趋势仍然存在（P = 0.004），但在进一步调整心肺适能后，这种趋势减弱（P = 0.06）。与最低力量组相比，最高力量组正常体重体重指数（BMI < 25）和超重或肥胖（BMI >= 25）男性发生代谢综合征的风险分别降低44%和39% （P < 0.05）。不同年龄层的发病率也呈负相关（20-39岁，P < 0.001； 40-49岁，P < 0.01； 50岁以上，P < 0.05）。结论：肌肉力量与代谢综合征发病率呈负相关，与年龄和体型无关。在代谢综合征的初级预防中，应该考虑到通过抗阻运动训练增强肌肉力量的潜在益处。
Purpose: To examine the association between muscular strength and incidence of metabolic syndrome.Methods: Participants were 3233 men (20-80 yr) initially free of metabolic syndrome who had two or more clinical examinations between 1980 and 2003, including baseline muscular strength and cardiorespiratory fitness assessment. Metabolic syndrome was defined according to NCEP-ATP III criteria. Muscular strength was quantified by combining body weight-adjusted one-repetition maximal measures for leg and bench presses. Cardiorespiratory fitness was assessed by maximal treadmill test.Results: A total of 480 men developed metabolic syndrome during a mean follow-up period of 6.7 +/- 5.2 yr. In a Cox regression analysis adjusted for age, the hazard ratios (95% confidence intervals) of metabolic syndrome associated with the incremental categories of muscular strength were 1.00 (referent), 0.88 (0.69-1.12), 0.77 (0.60-0.98), and 0.54 (0.42-0.71), respectively (linear trend P < 0.0001). The inverse trend persisted after adjustment for smoking, alcohol intake, number of baseline metabolic syndrome risk factors, family history of diabetes, hypertension, and premature coronary disease (P = 0.004), but was attenuated (P = 0.06) when further adjusted for cardiorespiratory fitness. Compared with the lowest strength category, the highest strength category was associated with 44 and 39% lower risk (P < 0.05 each) of incident metabolic syndrome among normal weight body mass index (BMI < 25) and overweight or obese (BMI >= 25) men, respectively. An inverse association of incident rates was also seen within stratum of age (20-39 yr, P < 0.001; 40-49 yr, P < 0.01; and 50+ yr, P < 0.05).Conclusions: Muscular strength was inversely associated with metabolic syndrome incidence, independent of age and body size. Potential benefits of greater muscular strength presumably through resistance exercise training should be considered in primary prevention of metabolic syndrome.