Changes in phosphate do not affect insulin release from isolated mouse islets of Langerhans.
Changes in phosphate do not affect insulin release from isolated mouse islets of Langerhans.
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磷酸盐的变化不会影响离体小鼠朗格汉斯岛的胰岛素释放。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
S. Sjunghall
中科院分区：
文献类型：
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作者：
B. Frankel;S. Sjunghall
磷酸盐影响糖耐量、胰岛素释放和外周胰岛素敏感性。在本研究中，孵育培养基的磷酸盐浓度从0.3至2 mmol/l（即，在生理范围内）不影响体外分离的小鼠胰岛的胰岛素释放。此外，动物的维生素D状态对不同磷酸盐浓度下葡萄糖刺激的胰岛素反应没有影响。因此，这些数据表明，在低磷酸盐血症状态下观察到的葡萄糖耐量受损不是由于磷水平对胰岛素释放B细胞的直接影响。
Phosphate affects glucose tolerance, insulin release and peripheral insulin sensitivity. In the present study moderate changes in the phosphate concentration of the incubation medium from 0.3 to 2 mmol/l (i.e., within the physiological range) did not affect insulin release from isolated mouse islets in vitro. In addition, the vitamin-D status of the animals had no effect on the glucose-stimulated insulin response in the different phosphate concentrations. Therefore these data indicate that the impaired glucose tolerance seen in hypophosphatemic states is not due to a direct effect of phosphorus levels on the insulin-releasing B-cell.