Preactivated and disaggregated shape-changed platelets protect kidney against from ischemia-reperfusion injury in rat through attenuating inflammation reaction
Preactivated and disaggregated shape-changed platelets protect kidney against from ischemia-reperfusion injury in rat through attenuating inflammation reaction
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DOI：
10.1002/term.2960
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发表时间：
2019-12-01
影响因子：
3.3
通讯作者：
Yip, Hon-Kan
中科院分区：
文献类型：
--
作者：
Chen, Yen-Ta;Yang, Chih-Chao;Yip, Hon-Kan
本研究验证了预活化和解聚的变形血小板（PreD-SCP）治疗对大鼠肾脏缺血再灌注（IR）损伤具有显著保护作用的假设。将成年雄性Sprague-Dawley大鼠（n = 24）等分为第1组（假手术对照[SC]）、第2组（SC + PreD-SCP）、第3组（仅IR）和第4组（IR + PreD-SCP）。在IR手术后72小时，第3组的肌酐、血尿氮和炎性生物标志物（白细胞介素[IL]-6/肿瘤坏死因子[TNF]-α）的循环水平以及尿蛋白/尿肌酐的比值显著高于其他组，第4组显著高于第1组和第2组，但第1组和第2组之间无差异（均为P > 0.05）。
This study tested the hypothesis that preactivated and disaggregated shape-changed platelet (PreD-SCP) therapy significantly protected rat kidney from ischemia-reperfusion (IR) injury. Adult-male Sprague-Dawley rats (n = 24) were equally categorized into Groups 1 (sham-operated control [SC]), 2 (SC + PreD-SCP), 3 (IR only), and 4 (IR + PreD-SCP). By 72 hr after IR procedure, the circulatory levels of creatinine, blood urine nitrogen and inflammatory biomarkers (interleukin [IL]-6/tumor necrosis factor [TNF]-alpha), and ratio of urine protein to urine creatinine were significantly higher in Group 3 than in other groups and significantly higher in Group 4 than in Groups 1 and 2, but they showed no different between Groups 1 and 2 (all p