Hypolipidemic activity of tetrakis-mu-(trimethylamine-boranecarboxylato)-bis(trimethylamin e- carboxyborane)-dicopper(II) in rodents and its effect on lipid metabolism.
Hypolipidemic activity of tetrakis-mu-(trimethylamine-boranecarboxylato)-bis(trimethylamin e- carboxyborane)-dicopper(II) in rodents and its effect on lipid metabolism.
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四-μ-(三甲胺-硼烷羧基)-双(三甲胺-e-羧基硼烷)-二铜(II)在啮齿类动物中的降血脂活性及其对脂质代谢的影响。
DOI：
10.1002/jps.2600730728
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发表时间：
1984
影响因子：
3.8
通讯作者：
Spielvogel,BF
中科院分区：
文献类型：
--
作者：
Hall,IH;WilliamsJr,WL;Gilbert,CJ;McPhail,AT;Spielvogel,BF
双核铜（II）配合物在大鼠和小鼠中以低剂量显示出有效的降血脂活性，即，2.5-10 mg/kg/d。该药物中度降低体内肝脏ATP依赖性柠檬酸裂解酶、乙酰辅酶A合成酶和磷脂酸磷酸水解酶活性。通过药物处理降低了动物的食欲，并且口服给药的肠胆固醇吸收显著降低。食糜和粪便中发现较高的脂质水平，表明药物（可能是胆汁途径）加速了脂质排泄。器官，例如，肝脏和小肠以及血清脂蛋白水平在给药后显示出较低的脂质含量。因此，这类化学药剂可能具有作为人类降血脂剂的潜力。
A binuclear copper(II) complex was shown to have potent hypolipidemic activity in rats and mice at low doses,i.e., 2.5–10 mg/kg/d. The agent moderately lowered liver ATP‐dependent citrate lyase, acetyl CoA synthetase, and phosphatidate phosphohydrolase activitiesin vivo. The appetite of the animal was reduced by drug treatment, and orally administered cholesterol absorption from the intestine was markedly lowered. Higher lipid levels were found in the chyme and the feces, indicating accelerated excretion of lipids by the drug, probablyviathe biliary route. Organs,e.g., liver and small intestine, as well as serum lipoprotein levels, demonstrated lower lipid content after drug administration. Thus, this chemical class of agents may have potential as a hypolipidemic agent in humans.