Differential dorsolateral prefrontal cortex activation during a verbal n-back task according to sensory modality
Differential dorsolateral prefrontal cortex activation during a verbal n-back task according to sensory modality
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根据感觉形态，言语 n-back 任务期间背外侧前额叶皮层激活的差异
DOI：
10.1016/j.bbr.2009.08.022
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发表时间：
2009
影响因子：
2.7
通讯作者：
T. Palomo
中科院分区：
文献类型：
--
作者：
R. Rodríguez;C. Ávila;C. García;A. Bagney;A. M. D. Aragón;N. Ventura‐Campos;I. Martínez;C. Forn;G. Ponce;G. Rubio;M. Jiménez‐Arriero;T. Palomo
对健康志愿者进行的功能性神经成像研究显示，在执行不同的n-back任务时，双侧额顶叶激活，特别是背外侧前额叶皮层（DLPFC）的激活具有共同的模式。我们的目的是使用功能性磁共振成像（fMRI）来比较大脑激活的模式，同时执行两个类似的n-back任务，不同的介绍方式。13名健康志愿者完成了口头2回任务，提出听觉刺激，和类似的2回任务，提出视觉刺激。联合分析显示，双侧激活额顶叶区，包括DLPFC。左侧DLPFC和上级颞回表现出更大的激活在听觉比在视觉条件下，而后脑区和前扣带回表现出更大的激活在视觉比在听觉任务。因此，参与n-back任务的视觉和听觉版本的大脑区域显示出它们之间的重要重叠，反映了工作记忆的超模态特征。然而，应考虑两种模式之间的差异，以便为未来的临床研究选择最合适的任务。
Functional neuroimaging studies carried out on healthy volunteers while performing different n-back tasks have shown a common pattern of bilateral frontoparietal activation, especially of the dorsolateral prefrontal cortex (DLPFC). Our objective was to use functional magnetic resonance imaging (fMRI) to compare the pattern of brain activation while performing two similar n-back tasks which differed in their presentation modality. Thirteen healthy volunteers completed a verbal 2-back task presenting auditory stimuli, and a similar 2-back task presenting visual stimuli. A conjunction analysis showed bilateral activation of frontoparietal areas including the DLPFC. The left DLPFC and the superior temporal gyrus showed a greater activation in the auditory than in the visual condition, whereas posterior brain regions and the anterior cingulate showed a greater activation during the visual than during the auditory task. Thus, brain areas involved in the visual and auditory versions of the n-back task showed an important overlap between them, reflecting the supramodal characteristics of working memory. However, the differences found between the two modalities should be considered in order to select the most appropriate task for future clinical studies.
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影响因子：
17.7
作者：
Yoon, Jong H.;Minzenberg, Michael J.;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
DOI：
10.1073/pnas.96.11.6558
发表时间：
1999-05-25
影响因子：
11.1
作者：
Rypma, B;D'Esposito, M
通讯作者：
D'Esposito, M
影响因子：
6.6
作者：
Potkin, S. G.;Turner, J. A.;Lim, K. O.
通讯作者：
Lim, K. O.
影响因子：
5.4
作者：
Glahn, DC;Bearden, CE;Soares, JC
通讯作者：
Soares, JC