Comparison between the antiemetic effects of palonosetron and granisetron in breast cancer patients treated with anthracycline-based regimens.
Comparison between the antiemetic effects of palonosetron and granisetron in breast cancer patients treated with anthracycline-based regimens.
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DOI：
10.3892/ol.2014.2640
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发表时间：
2015-01
期刊：
影响因子：
2.9
通讯作者：
Yasuda Y
中科院分区：
文献类型：
--
作者：
Ohzawa H;Miki A;Hozumi Y;Miyazaki C;Sagara Y;Tanaka Y;Shiba S;Joutoku H;Sakuragi M;Takehara M;Sakuma Y;Nishimura W;Fujii H;Yasuda Y
化疗引起的恶心和呕吐是乳腺癌患者蒽环类药物化疗方案的一种严重不良反应。止吐治疗推荐联合使用5-羟色胺（5-HT 3）受体拮抗剂、阿瑞匹坦和地塞米松。帕洛诺司琼（Palonosetron，PALO）是一种新型的5-HT_3受体拮抗剂，具有抗迟发性恶心呕吐的作用。在这项研究中，PALO的结果谁接受蒽环类药物为基础的化疗患者进行了比较，格拉司琼（GRA）采用交叉研究设计。本研究评价了止吐药在第一周期化疗以及第二和第三周期化疗中的疗效。在第一个化疗周期中，共有21例患者和19例患者分别被分配到PALO和GRA治疗组。患者在第二个化疗周期转换为另一种止吐药物（PALO后GRA或GRA后PALO）。第三周期可根据患者的喜好选择PALO或GRA止吐药。第三周期共有21例患者选择PALO，18例患者选择GRA，1例患者因未获得第三周期问卷而退出研究。PALO和GRA在第一个和第二个周期中没有显著差异。然而，在第三个周期中，观察到PALO组和GRA组之间急性期呕吐事件完全控制的显著差异，其定义为PALO组和GRA组之间无呕吐发作、无额外止吐治疗和不超过轻度恶心。这些结果表明，改变止吐药可能会影响止吐药的疗效。本研究表明，止吐方案的改变，包括药物组合和顺序，可能会提高止吐治疗的疗效。
Chemotherapy-induced nausea and vomiting is a serious adverse side-effect of anthracycline-based chemotherapy regimens, in patients with breast cancer. A combination of three drugs, 5-hydroxytryptamine (5-HT3) receptor antagonist, aprepitant and dexamethasone, is recommended for antiemetic therapy. Palonosetron (PALO), a novel 5-HT3 receptor antagonist has been identified to be effective against delayed nausea and vomiting. In this study, the results of PALO for patients who received anthracycline-based chemotherapy were compared with that of granisetron (GRA) using a crossover study design. This study evaluated the efficacy of antiemetics in the first cycle of chemotherapy, as well as the second and third cycles. A total of 21 patients and 19 patients were assigned to PALO and GRA treatment groups during the first cycle of chemotherapy, respectively. The patients switched to the other antiemetic drug for the second chemotherapy cycle (PALO followed by GRA or GRA followed by PALO). The patients could select PALO or GRA antiemetics for the third cycle, according to their preference. A total of 21 patients selected PALO and 18 patients selected GRA in the third cycle, and one patient was withdrawn from the study as their third cycle questionnaire was not obtained. No significant differences between PALO and GRA were identified in first and second cycles. However, during the third cycle, a significant difference was observed in acute-phase complete control of emetic events between the PALO and GRA groups, which was defined as no emetic episode, no additional antiemetic treatment and no more than mild nausea, between PALO and GRA. These results demonstrated that changing antiemetics may affect the efficacy of antiemetics. This study indicates that alteration of antiemetic regimens, including drug combination and order, may improve the efficacy of antiemetic treatment.
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DOI：
10.1124/jpet.110.166181
发表时间：
2010-11-01
影响因子：
3.5
作者：
Rojas, Camilo;Li, Ying;Slusher, Barbara S.
通讯作者：
Slusher, Barbara S.
影响因子：
3.1
作者：
Cohen, Lorenzo;de Moor, Carl A.;Hu, Henry
通讯作者：
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影响因子：
7.3
作者：
Hothersall JD;Moffat C;Connolly CN
通讯作者：
Connolly CN
影响因子：
51.1
作者：
Saito, Mitsue;Aogi, Kenjiro;Mitsuhashi, Shoichi
通讯作者：
Mitsuhashi, Shoichi
影响因子：
--
作者：
Langford P;Chrisp P
通讯作者：
Chrisp P