Clinicopathologic characteristics of invasive lobular carcinoma of the breast - Results of an analysis of 530 cases from a single institution
Clinicopathologic characteristics of invasive lobular carcinoma of the breast - Results of an analysis of 530 cases from a single institution
复制标题
DOI：
10.1002/cncr.23811
复制
发表时间：
2008-10-01
期刊：
影响因子：
6.2
通讯作者：
Viale, Giuseppe
中科院分区：
文献类型：
--
作者：
Orvieto, Enrico;Maiorano, Eugenio;Viale, Giuseppe
背景。尽管浸润性小叶癌（ILC）是第二常见的乳腺癌组织型，但其临床病理特征对预后的影响仍存在争议。作者对在一家机构接受治疗和随访的大量病例进行了回顾性分析，目的是在对原始组织病理准备和统计分析进行修订后，评估肿瘤不同临床病理特征的预后/预测价值。总的来说，530例纯ILC患者（57%为经典型，19%为肺泡型，11%为实型，其余13%以多形性、印环细胞、组织细胞样或大汗液特征为特征）被纳入研究。肿瘤大小、淋巴结转移和激素水平被证实是重要的预后因素。此外，ILC的“经典”组织型与较低的腋窝淋巴结转移风险（P = 0.0005）、转移淋巴结数量减少（P = 0.04）和较低的肿瘤分级（P = 0.0005）之间存在统计学上显著的相关性
BACKGROUND. Although invasive lobular carcinoma (ILC) is the second most common histotype of breast cancer, the prognostic implications of its clinicopathologic characteristics remain controversial.METHODS. The authors undertook a retrospective analysis of a large series of cases treated and followed at a single institution, with the objective of assessing the prognostic/predictive value of distinct clinicopathologic features of the tumors, after revision of the original histopathologic preparations and statistical analyses.RESULTS. Overall, 530 patients with pure ILC (57% with the classic type; 19% with the alveolar type; 11% with the solid type; and the remaining 13% characterized by pleomorphic, signet ring cell, histiocytoid, or apocrine features) were included in the study. Tumor size, lymph node metastatic involvement, and hormonal status were confirmed to be significant prognostic factors. In addition, statistically significant correlations were demonstrated between the 'classic' histotype of ILC and a lower risk of axillary lymph node metastases (P =.0005), a reduced number of metastatic lymph nodes (P =.04), and lower tumor grade (P